Personalized Biobehavioral HIV Prevention for Women and Adolescent Girls

Overview

Journal Glob Adv Health Med

Specialty Public Health

Date 2014 Jan 14

PMID 24416702

Citations 6

Authors

Bridgette M Brawner

Anne M Teitelman

Amanda W Bevilacqua

Loretta Sweet Jemmott

Affiliations

Soon will be listed here.

Abstract

Background: Women and adolescent girls bear a significant burden of the global HIV pandemic. Both behavioral and biomedical prevention approaches have been shown to be effective. In order to foster the most effective combination HIV-prevention approaches for women and girls, it is imperative to understand the unique biological, social, and structural considerations that increase vulnerability to acquiring HIV within this population.

Primary Study Objective: The purpose of this article is to propose novel ideas for personalized biobehavioral HIV prevention for women and adolescent girls. The central argument is that we must transcend unilevel solutions for HIV prevention toward comprehensive, multilevel combination HIV prevention packages to actualize personalized biobehavioral HIV prevention. Our hope is to foster transnational dialogue among researchers, practitioners, educators, and policy makers toward the actualization of the proposed recommendations.

Methods: We present a commentary organized to review biological, social, and structural factors that increase vulnerability to HIV acquisition among women and adolescent girls. The overview is followed by recommendations to curb HIV rates in the target population in a sustainable manner.

Results: The physiology of the lower female reproductive system biologically increases HIV risk among women and girls. Social (eg, intimate partner violence) and structural (eg, gender inequality) factors exacerbate this risk by increasing the likelihood of viral exposure. Our recommendations for personalized biobehavioral HIV prevention are to (1) create innovative mechanisms for personalized HIV risk-reduction assessments; (2) develop mathematical models of local epidemics; (3) prepare personalized, evidence-based combination HIV risk-reduction packages; (4) structure gender equity into society; and (5) eliminate violence (both physical and structural) against women and girls.

Conclusions: Generalized programs and interventions may not have universal, transnational, and crosscultural implications. Personalized biobehavioral strategies are needed to comprehensively address vulnerabilities at biological, social, and structural levels.

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Brawner B, Sommers M, Moore K, Aka-James R, Zink T, Brown K J Acquir Immune Defic Syndr. 2015; 71(2):207-12.

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The Role of Sexual Health Professionals in Developing a Shared Concept of Risky Sexual Behavior as it Relates to HIV Transmission.

Brawner B, Alexander K, Fannin E, Baker J, Davis Z Public Health Nurs. 2015; 33(2):139-50.

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References

Auerbach J, Parkhurst J, Caceres C . Addressing social drivers of HIV/AIDS for the long-term response: conceptual and methodological considerations. Glob Public Health. 2011; 6 Suppl 3:S293-309. DOI: 10.1080/17441692.2011.594451. View

Impett E, Schooler D, Tolman D . To be seen and not heard: femininity ideology and adolescent girls' sexual health. Arch Sex Behav. 2006; 35(2):131-44. DOI: 10.1007/s10508-005-9016-0. View

H Gray R, Li X, Kigozi G, Serwadda D, Brahmbhatt H, Wabwire-Mangen F . Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study. Lancet. 2005; 366(9492):1182-8. DOI: 10.1016/S0140-6736(05)67481-8. View

Wingood G, Scd , DiClemente R . Application of the theory of gender and power to examine HIV-related exposures, risk factors, and effective interventions for women. Health Educ Behav. 2000; 27(5):539-65. DOI: 10.1177/109019810002700502. View

Machtinger E, Wilson T, Haberer J, Weiss D . Psychological trauma and PTSD in HIV-positive women: a meta-analysis. AIDS Behav. 2012; 16(8):2091-100. DOI: 10.1007/s10461-011-0127-4. View

Maticka-Tyndale E, Tenkorang E . A multi-level model of condom use among male and female upper primary school students in Nyanza, Kenya. Soc Sci Med. 2010; 71(3):616-625. DOI: 10.1016/j.socscimed.2010.03.049. View

Wira C, Fahey J, Sentman C, Pioli P, Shen L . Innate and adaptive immunity in female genital tract: cellular responses and interactions. Immunol Rev. 2005; 206:306-35. DOI: 10.1111/j.0105-2896.2005.00287.x. View

Jemmott L, Jemmott 3rd J, OLeary A . Effects on sexual risk behavior and STD rate of brief HIV/STD prevention interventions for African American women in primary care settings. Am J Public Health. 2007; 97(6):1034-40. PMC: 1874197. DOI: 10.2105/AJPH.2003.020271. View

Wyatt G, Gomez C, Hamilton A, Valencia-Garcia D, Gant L, Graham C . The intersection of gender and ethnicity in HIV risk, interventions, and prevention: new frontiers for psychology. Am Psychol. 2013; 68(4):247-60. DOI: 10.1037/a0032744. View

10.

Vissers D, Voeten H, Nagelkerke N, Habbema J, de Vlas S . The impact of pre-exposure prophylaxis (PrEP) on HIV epidemics in Africa and India: a simulation study. PLoS One. 2008; 3(5):e2077. PMC: 2367053. DOI: 10.1371/journal.pone.0002077. View

11.

Decker M, Seage 3rd G, Hemenway D, Gupta J, Raj A, Silverman J . Intimate partner violence perpetration, standard and gendered STI/HIV risk behaviour, and STI/HIV diagnosis among a clinic-based sample of men. Sex Transm Infect. 2009; 85(7):555-60. PMC: 3623286. DOI: 10.1136/sti.2009.036368. View

12.

Quinn T, Overbaugh J . HIV/AIDS in women: an expanding epidemic. Science. 2005; 308(5728):1582-3. DOI: 10.1126/science.1112489. View

13.

Elakkary S, Franke B, Shokri D, Hartwig S, Tsokos M, Puschel K . Honor crimes: review and proposed definition. Forensic Sci Med Pathol. 2013; 10(1):76-82. DOI: 10.1007/s12024-013-9455-1. View

14.

Das M, Chu P, Santos G, Scheer S, Vittinghoff E, McFarland W . Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco. PLoS One. 2010; 5(6):e11068. PMC: 2883572. DOI: 10.1371/journal.pone.0011068. View

15.

Yeaman G, Howell A, Weldon S, Demian D, Collins J, OConnell D . Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infection. Immunology. 2003; 109(1):137-46. PMC: 1782948. DOI: 10.1046/j.1365-2567.2003.01623.x. View

16.

. Interim guidance for clinicians considering the use of preexposure prophylaxis for the prevention of HIV infection in heterosexually active adults. MMWR Morb Mortal Wkly Rep. 2012; 61(31):586-9. View

17.

Sareen J, Pagura J, Grant B . Is intimate partner violence associated with HIV infection among women in the United States?. Gen Hosp Psychiatry. 2009; 31(3):274-8. DOI: 10.1016/j.genhosppsych.2009.02.004. View

18.

Bowleg L, Raj A . Shared communities, structural contexts, and HIV risk: prioritizing the HIV risk and prevention needs of Black heterosexual men. Am J Public Health. 2012; 102 Suppl 2:S173-7. PMC: 3477914. DOI: 10.2105/AJPH.2011.300342. View

19.

Diouf K, Nour N . Female genital cutting and HIV transmission: is there an association?. Am J Reprod Immunol. 2012; 69 Suppl 1:45-50. DOI: 10.1111/aji.12028. View

20.

Galindo G, Garrett-Walker J, Hazelton P, Lane T, Steward W, Morin S . Community member perspectives from transgender women and men who have sex with men on pre-exposure prophylaxis as an HIV prevention strategy: implications for implementation. Implement Sci. 2012; 7:116. PMC: 3527231. DOI: 10.1186/1748-5908-7-116. View