Rhamnogalacturonan from Acmella Oleracea (L.) R.K. Jansen: Gastroprotective and Ulcer Healing Properties in Rats

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jan 14

PMID 24416280

Citations 7

Authors

Daniele Maria-Ferreira

Luisa Mota da Silva

Daniel Augusto Gasparin Bueno Mendes

Daniela de Almeida Cabrini

Adamara Machado Nascimento

Marcello Iacomini

Thales Ricardo Cipriani

Adair Roberto Soares Santos

Maria Fernanda de Paula Werner

Cristiane Hatsuko Baggio

Affiliations

Soon will be listed here.

Abstract

A rhamnogalacturonan (RGal) isolated from Acmella oleracea (L.) R.K. Jansen administered by oral route showed gastroprotective activity against acute lesions induced by ethanol. In this study, we investigated the gastric ulcer healing effect of RGal and its mechanisms of action. Intraperitoneal treatment of animals with RGal protected the gastric mucosa against acute lesions induced by ethanol, with participation of gastric mucus. Furthermore, in the chronic ulcer model, oral administration of RGal accelerates the gastric ulcer healing, accompanied by increasing of cellular proliferation and gastric mucus content, reducing inflammatory parameters and oxidative stress. In addition, the repeated 7 days-treatment of animals with RGal did not show alterations of clinical and behavioral symptoms, body and organs weights or plasmatic biochemical parameters. Collectively, these results showed that RGal has an interesting antiulcerogenic activity and could constitute an attractive molecule of interest for the development of new antiulcer agents.

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