Role for Mycobacterium Tuberculosis Membrane Vesicles in Iron Acquisition

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2014 Jan 14

PMID 24415729

Citations 109

Authors

Rafael Prados-Rosales

Brian C Weinrick

Daniel G Pique

William R Jacobs Jr

Arturo Casadevall

G Marcela Rodriguez

Affiliations

Soon will be listed here.

Abstract

Mycobacterium tuberculosis releases membrane vesicles packed with molecules that can modulate the immune response. Because environmental conditions often influence the production and content of bacterial vesicles, this study examined M. tuberculosis microvesicles released under iron limitation, a common condition faced by pathogens inside the host. The findings indicate that M. tuberculosis increases microvesicle production in response to iron restriction and that these microvesicles contain mycobactin, which can serve as an iron donor and supports replication of iron-starved mycobacteria. Consequently, the results revealed a role of microvesicles in iron acquisition in M. tuberculosis, which can be critical for survival in the host.

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