Production of Clavulanic Acid and Cephamycin C by Streptomyces Clavuligerus in Palm-oil Medium

Overview

Journal World J Microbiol Biotechnol

Publisher Springer

Specialties Biotechnology
Microbiology

Date 2014 Jan 14

PMID 24415093

Citations 4

Authors

P C Lee

C C Ho

Affiliations

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Abstract

Palm and palm-kernel oils and their olein and stearin fractions were suitable as the main carbon sources for growth and production of clavulanic acid by Streptomyces clavuligerus. However, oleic and lauric acids were not utilized for growth. A spontaneous mutant, which was selected for higher cephamycin C production, also produced more clavulanic acid with these oils in the medium.

Citing Articles

Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1.

Fu J, Xie X, Zhang S, Kang N, Zong G, Zhang P Microbiol Spectr. 2022; 11(1):e0201722.

PMID: 36515504 PMC: 9927107. DOI: 10.1128/spectrum.02017-22.

Production of β-Lactamase Inhibitors by Species.

Marques D, Feitosa Machado S, Ebinuma V, de Albuquerque Lima Duarte C, Converti A, Figueiredo Porto A Antibiotics (Basel). 2018; 7(3).

PMID: 30018235 PMC: 6163296. DOI: 10.3390/antibiotics7030061.

Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review.

Ser H, Law J, Chaiyakunapruk N, Jacob S, Palanisamy U, Chan K Front Microbiol. 2016; 7:522.

PMID: 27148211 PMC: 4840625. DOI: 10.3389/fmicb.2016.00522.

Screening of wild type Streptomyces isolates able to overproduce clavulanic acid.

Marques D, Santos-Ebinuma V, de Oliveira P, de Souza Lima G, Araujo J, Lima-Filho J Braz J Microbiol. 2014; 45(3):919-28.

PMID: 25477926 PMC: 4204977. DOI: 10.1590/s1517-83822014000300022.

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