Regional Gray Matter Volume is Associated with Empathizing and Systemizing in Young Adults

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jan 11

PMID 24409308

Citations 30

Authors

Hikaru Takeuchi

Yasuyuki Taki

Yuko Sassa

Hiroshi Hashizume

Atsushi Sekiguchi

Ai Fukushima

Ryuta Kawashima

Affiliations

Soon will be listed here.

Abstract

Empathizing is defined as the drive to identify the mental states of others for predicting their behavior and responding with an appropriate emotion. Systemizing is defined as the drive to analyze a system in terms of the rules that govern the system in order to predict its behavior. Using voxel-based morphometry and questionnaires in a large sample of normal, right-handed young adults, we investigated the regional gray matter volume (rGMV) correlates of empathizing and systemizing and additionally those of the D score, which is the difference between systemizing and empathizing, to reveal the comprehensive picture of those correlates. Negative rGMV correlates of empathizing and positive rGMV correlates of the D score (formed by the negative correlation between rGMV and empathizing), were found primarily in nodes in the default mode network, mirror neuron system, dorsal anterior cingulate cortex, and the lateral part of the prefrontal cortex together with other areas. Positive rGMV correlates of systemizing and of the D score (formed by the positive correlation between rGMV and systemizing) were found primarily in nodes in the external attention system, middle cingulate cortex, and other regions. Negative rGMV correlates of systemizing were found in an area close to the left posterior insula and putamen. These findings reconcile some previously inconsistent findings, provide other new findings and suggest that these areas contribute to empathizing-systemizing. Furthermore, the negative/positive rGMV correlates of empathizing and positive/negative rGMV correlates of systemizing overlapped substantially. This may be in line with the notion that empathizing and systemizing compete neurally in the brain.

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References

Wheelwright S, Baron-Cohen S, Goldenfeld N, Delaney J, Fine D, Smith R . Predicting Autism Spectrum Quotient (AQ) from the Systemizing Quotient-Revised (SQ-R) and Empathy Quotient (EQ). Brain Res. 2006; 1079(1):47-56. DOI: 10.1016/j.brainres.2006.01.012. View

Nickl-Jockschat T, Habel U, Michel T, Manning J, Laird A, Fox P . Brain structure anomalies in autism spectrum disorder--a meta-analysis of VBM studies using anatomic likelihood estimation. Hum Brain Mapp. 2011; 33(6):1470-89. PMC: 4801488. DOI: 10.1002/hbm.21299. View

Baron-Cohen S, Richler J, Bisarya D, Gurunathan N, Wheelwright S . The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences. Philos Trans R Soc Lond B Biol Sci. 2003; 358(1430):361-74. PMC: 1693117. DOI: 10.1098/rstb.2002.1206. View

Wagner D, Kelley W, Heatherton T . Individual differences in the spontaneous recruitment of brain regions supporting mental state understanding when viewing natural social scenes. Cereb Cortex. 2011; 21(12):2788-96. PMC: 3209798. DOI: 10.1093/cercor/bhr074. View

Zhou Y, Wang K, Liu Y, Song M, Song S, Jiang T . Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders. Cogn Neurodyn. 2011; 4(4):275-94. PMC: 2974101. DOI: 10.1007/s11571-010-9126-9. View

Pujol J, Lopez A, Deus J, Cardoner N, Vallejo J, Capdevila A . Anatomical variability of the anterior cingulate gyrus and basic dimensions of human personality. Neuroimage. 2002; 15(4):847-55. DOI: 10.1006/nimg.2001.1004. View

Ambery F, Russell A, Perry K, Morris R, Murphy D . Neuropsychological functioning in adults with Asperger syndrome. Autism. 2006; 10(6):551-64. DOI: 10.1177/1362361306068507. View

Amodio D, Frith C . Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006; 7(4):268-77. DOI: 10.1038/nrn1884. View

Haruno M, Kawato M . Different neural correlates of reward expectation and reward expectation error in the putamen and caudate nucleus during stimulus-action-reward association learning. J Neurophysiol. 2005; 95(2):948-59. DOI: 10.1152/jn.00382.2005. View

10.

Schultheiss O, Wirth M, Waugh C, Stanton S, Meier E, Reuter-Lorenz P . Exploring the motivational brain: effects of implicit power motivation on brain activation in response to facial expressions of emotion. Soc Cogn Affect Neurosci. 2008; 3(4):333-43. PMC: 2607053. DOI: 10.1093/scan/nsn030. View

11.

Kanai R, Bahrami B, Duchaine B, Janik A, Banissy M, Rees G . Brain structure links loneliness to social perception. Curr Biol. 2012; 22(20):1975-9. PMC: 3510434. DOI: 10.1016/j.cub.2012.08.045. View

12.

Zaki J, Weber J, Bolger N, Ochsner K . The neural bases of empathic accuracy. Proc Natl Acad Sci U S A. 2009; 106(27):11382-7. PMC: 2708723. DOI: 10.1073/pnas.0902666106. View

13.

Aydin K, Ucar A, Oguz K, Okur O, Agayev A, Unal Z . Increased gray matter density in the parietal cortex of mathematicians: a voxel-based morphometry study. AJNR Am J Neuroradiol. 2007; 28(10):1859-64. PMC: 8134244. DOI: 10.3174/ajnr.A0696. View

14.

Genovese C, Lazar N, Nichols T . Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage. 2002; 15(4):870-8. DOI: 10.1006/nimg.2001.1037. View

15.

Ashburner J, Friston K . Voxel-based morphometry--the methods. Neuroimage. 2000; 11(6 Pt 1):805-21. DOI: 10.1006/nimg.2000.0582. View

16.

Wakabayashi A, Baron-Cohen S, Wheelwright S . [Individual and gender differences in Empathizing and Systemizing: measurement of individual differences by the Empathy Quotient (EQ) and the Systemizing Quotient (SQ)]. Shinrigaku Kenkyu. 2006; 77(3):271-7. DOI: 10.4992/jjpsy.77.271. View

17.

Redcay E, Courchesne E . When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol Psychiatry. 2005; 58(1):1-9. DOI: 10.1016/j.biopsych.2005.03.026. View

18.

Baron-Cohen S, Wheelwright S . The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J Autism Dev Disord. 2004; 34(2):163-75. DOI: 10.1023/b:jadd.0000022607.19833.00. View

19.

Fornito A, Yung A, Wood S, Phillips L, Nelson B, Cotton S . Anatomic abnormalities of the anterior cingulate cortex before psychosis onset: an MRI study of ultra-high-risk individuals. Biol Psychiatry. 2008; 64(9):758-65. DOI: 10.1016/j.biopsych.2008.05.032. View

20.

Zeki S, Romaya J . Neural correlates of hate. PLoS One. 2008; 3(10):e3556. PMC: 2569212. DOI: 10.1371/journal.pone.0003556. View