A Prospective Study of Dextran-induced Anaphylactoid Reactions in 5745 Patients

Overview

Journal Anaesth Intensive Care

Publisher Sage Publications

Specialties Anesthesiology
Critical Care

Date 1987 May 1

PMID 2440337

Citations 10

Authors

J Paull

Affiliations

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Abstract

A prospective study of dextran-induced anaphylactoid reactions (DIAR) in 5745 gynaecological and obstetric patients who received dextran 70 solution intravenously while undergoing major surgery revealed 8 patients who had Grade I or II reactions and 7 patients who had Grade III or IV reactions. The incidence of severe reactions was 1:821 patients treated. The overall incidence of reactions per patient treated was 1:383. One neonatal death followed a dextran-induced cardiac arrest in a woman about to undergo caesarean section. The risks of dextran 70 treatment exceeded the risks of thromboembolism in these patients.

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