Cumulative Lead Exposure and Age at Menopause in the Nurses' Health Study Cohort

Overview

Journal Environ Health Perspect

Date 2014 Jan 9

PMID 24398113

Citations 11

Authors

Ki-Do Eum

Marc G Weisskopf

Linda H Nie

Howard Hu

Susan A Korrick

Affiliations

Soon will be listed here.

Abstract

Background: Early menopause has been associated with many adverse health outcomes, including increased risk of cardiovascular disease morbidity and mortality. Lead has been found to be adversely associated with female reproductive function, but whether exposures experienced by the general population are associated with altered age at menopause has not been explored.

Objective: Our goal was to assess the association between cumulative lead exposure and age at natural menopause.

Methods: Self-reported menopausal status and bone lead concentration measured with K-shell X-ray fluorescence-a biomarker of cumulative lead exposure-were obtained from 434 women participants in the Nurses' Health Study.

Results: The mean (± SD) age at natural menopause was 50.8 ± 3.6 years. Higher tibia lead level was associated with younger age at menopause. In adjusted analyses, the average age of menopause for women in the highest tertile of tibia lead was 1.21 years younger (95% CI: -2.08, -0.35) than for women in the lowest tertile (p-trend = 0.006). Although the number of cases was small (n = 23), the odds ratio for early menopause (< 45 years of age) was 5.30 (95% CI: 1.42, 19.78) for women in the highest tertile of tibia lead compared with those in the lowest tertile (p-trend = 0.006). There was no association between patella or blood lead and age at menopause.

Conclusions: Our results support an association between low-level cumulative lead exposure and an earlier age at menopause. These data suggest that low-level lead exposure may contribute to menopause-related health outcomes in older women through effects on age at menopause.

Citation: Eum KD, Weisskopf MG, Nie LH, Hu H, Korrick SA. 2014. Cumulative lead exposure and age at menopause in the Nurses' Health Study Cohort. Environ Health Perspect 122:229–234; http://dx.doi.org/10.1289/ehp.1206399

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