Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2014 Jan 8

PMID 24396340

Citations 11

Authors

Jialie Luo

Edgar T Walters

Susan M Carlton

Hongzhen Hu

Affiliations

Soon will be listed here.

Abstract

Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as molecular sensors of tissue damage and inflammation. Activation/sensitization of TRP channels in peripheral nociceptors produces neurogenic inflammation and contributes to both somatic and visceral pain. Pharmacological and genetic studies have affirmed the role of TRP channels in multiple forms of inflammatory and neuropathic pain. Thus pain-evoking TRP channels emerge as promising therapeutic targets for a wide variety of pain and inflammatory conditions.

Citing Articles

Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation.

Kim S, Chung G, Kim S Front Pain Res (Lausanne). 2025; 6:1537154.

PMID: 39958366 PMC: 11825757. DOI: 10.3389/fpain.2025.1537154.

Lipid raft disruption inhibits the activation of Transient Receptor Potential Vanilloid 1, but not TRP Melastatin 3 and the voltage-gated L-type calcium channels in sensory neurons.

Payrits M, Zsido B, Nehr-Majoros A, Borzsei R, Helyes Z, Hetenyi C Front Cell Dev Biol. 2024; 12:1452306.

PMID: 39676793 PMC: 11638188. DOI: 10.3389/fcell.2024.1452306.

Analgesic and anti-inflammatory effects of galangin: a potential pathway to inhibit transient receptor potential vanilloid 1 receptor activation.

Lin K, Fu D, Wang Z, Zhang X, Zhu C Korean J Pain. 2024; 37(2):151-163.

PMID: 38557656 PMC: 10985483. DOI: 10.3344/kjp.23363.

Cyclodextrin derivatives decrease Transient Receptor Potential vanilloid 1 and Ankyrin 1 ion channel activation via altering the surrounding membrane microenvironment by cholesterol depletion.

Nehr-Majoros A, Erostyak J, Fenyvesi E, Szabo-Meleg E, Szocs L, Setalo Jr G Front Cell Dev Biol. 2024; 12:1334130.

PMID: 38481530 PMC: 10933000. DOI: 10.3389/fcell.2024.1334130.

A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain.

Hu X, Du L, Liu S, Lan Z, Zang K, Feng J J Clin Invest. 2023; 133(5.

PMID: 36701202 PMC: 9974096. DOI: 10.1172/JCI161507.

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