Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition Through Activating the MAPK Signaling Pathway

Overview

Journal Mol Med

Publisher Biomed Central

Specialties General Medicine
Molecular Biology

Date 2014 Jan 8

PMID 24395568

Citations 16

Authors

Zhenwei Zhang

Lei Miao

Xiaoming Xin

Jianpeng Zhang

Shengsheng Yang

Mingyong Miao

Xiangping Kong

Binghua Jiao

Affiliations

Soon will be listed here.

Abstract

Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic expression of CNDP2 resulted in significant inhibition of cell proliferation, induction of cell apoptosis and cell cycle arrest, and suppressed gastric tumor growth in nude mice. We further revealed that the reintroduction of CNDP2 transcriptionally upregulated p38 and activated c-Jun NH2-terminal kinase (JNK), whereas the loss of CNDP2 increased the phosphorylation of extracellular signal-related kinase (ERK). These results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.

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