[15]aneN4S: Synthesis, Thermodynamic Studies and Potential Applications in Chelation Therapy

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2014 Jan 8

PMID 24394438

Citations 1

Authors

Nuno Torres

Sandrina Goncalves

Ana S Fernandes

J Franco Machado

Maria J Villa de Brito

Nuno G Oliveira

Matilde Castro

Judite Costa

Maria F Cabral

Affiliations

Soon will be listed here.

Abstract

The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN4S with Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+ and Pb2+ metal ions were further performed under the same experimental conditions. The results demonstrated that this compound has a higher selectivity and thermodynamic stability for Hg2+ and Cu2+, followed by Ni2+. The UV-visible-near IR spectroscopies and magnetic moment data for the Co(II) and Ni(II) complexes indicated a tetragonal distorted coordination geometry for both metal centres. The value of magnetic moment and the X-band EPR spectra of the Cu(II) complex are consistent with a distorted square pyramidal geometry.

Citing Articles

In Vitro Assessment of the Efficacy of a Macrocyclic Chelator in Reversing Methylmercury Toxicity.

Nobre P, Cabral M, Costa J, Castro-Caldas M, Carvalho C, Branco V Int J Environ Res Public Health. 2019; 16(23).

PMID: 31801208 PMC: 6926914. DOI: 10.3390/ijerph16234817.

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