Inhibitory Control in Bulimic-type Eating Disorders: a Systematic Review and Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jan 7

PMID 24391763

Citations 74

Authors

Mudan Wu

Mechthild Hartmann

Mandy Skunde

Wolfgang Herzog

Hans-Christoph Friederich

Affiliations

Soon will be listed here.

Abstract

The aim of this meta-analysis was to summarise data from neuropsychological studies on inhibitory control to general and disease-salient (i.e., food/eating, body/shape) stimuli in bulimic-type eating disorders (EDs). A systematic literature search was conducted to identify eligible experimental studies. The outcome measures studied included the performance on established inhibitory control tasks in bulimic-type EDs. Effect sizes (Hedges' g) were pooled using random-effects models. For inhibitory control to general stimuli, 24 studies were included with a total of 563 bulimic-type ED patients: 439 had bulimia nervosa (BN), 42 had anorexia nervosa of the binge/purge subtype (AN-b), and 82 had binge eating disorder (BED). With respect to inhibitory control to disease-salient stimuli, 12 studies were included, representing a total of 218 BN patients. A meta-analysis of these studies showed decreased inhibitory control to general stimuli in bulimic-type EDs (g = -0.32). Subgroup analysis revealed impairments with a large effect in the AN-b group (g = -0.91), impairments with a small effect in the BN group (g = -0.26), and a non-significant effect in the BED group (g = -0.16). Greater impairments in inhibitory control were observed in BN patients when confronted with disease-salient stimuli (food/eating: g = -0.67; body/shape: g = -0.61). In conclusion, bulimic-type EDs showed impairments in inhibitory control to general stimuli with a small effect size. There was a significantly larger impairment in inhibitory control to disease salient stimuli observed in BN patients, constituting a medium effect size.

Citing Articles

Exploring the relationship between proactive inhibition and restrictive eating behaviours in severe and enduring anorexia nervosa (SE-AN).

Bartholdy S, Dalton B, Rennalls S, Kekic M, McClelland J, Campbell I J Eat Disord. 2025; 13(1):1.

PMID: 39754276 PMC: 11699635. DOI: 10.1186/s40337-024-01165-y.

Expressive Suppression of Emotions in Bulimia Nervosa: An Electroencephalography Study.

Desdentado L, Pollatos O J Clin Psychol. 2024; 81(3):158-170.

PMID: 39703155 PMC: 11802486. DOI: 10.1002/jclp.23761.

Neural Correlates of Emotion Regulation and Associations With Disordered Eating During Preadolescence.

Thomas K, Jones C, Williams M, Vanderwert R Dev Psychobiol. 2024; 67(1):e70009.

PMID: 39648280 PMC: 11625878. DOI: 10.1002/dev.70009.

Reward and Inhibitory Control as Mechanisms and Treatment Targets for Binge Eating Disorder.

Pasquale E, Boyar A, Boutelle K Curr Psychiatry Rep. 2024; 26(11):616-625.

PMID: 39316228 PMC: 11579074. DOI: 10.1007/s11920-024-01534-z.

Meta-analysis of variance in tDCS effects on response inhibition.

Lasogga L, Gramegna C, Muller D, Habel U, Mehler D, Gur R Sci Rep. 2024; 14(1):19197.

PMID: 39160262 PMC: 11333595. DOI: 10.1038/s41598-024-70065-7.

References

Van Den Eynde F, Claudino A, Mogg A, Horrell L, Stahl D, Ribeiro W . Repetitive transcranial magnetic stimulation reduces cue-induced food craving in bulimic disorders. Biol Psychiatry. 2010; 67(8):793-5. DOI: 10.1016/j.biopsych.2009.11.023. View

Cooper M, Anastasiades P, Fairburn C . Selective processing of eating-, shape-, and weight-related words in persons with bulimia nervosa. J Abnorm Psychol. 1992; 101(2):352-5. DOI: 10.1037//0021-843x.101.2.352. View

Starkstein S, Robinson R . Mechanism of disinhibition after brain lesions. J Nerv Ment Dis. 1997; 185(2):108-14. DOI: 10.1097/00005053-199702000-00007. View

Marsh R, Horga G, Wang Z, Wang P, Klahr K, Berner L . An FMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa. Am J Psychiatry. 2011; 168(11):1210-20. PMC: 3328859. DOI: 10.1176/appi.ajp.2011.11010094. View

Casey B, Trainor R, Orendi J, Schubert A, Nystrom L, Giedd J . A Developmental Functional MRI Study of Prefrontal Activation during Performance of a Go-No-Go Task. J Cogn Neurosci. 2013; 9(6):835-47. DOI: 10.1162/jocn.1997.9.6.835. View

Crow S, Peterson C, Swanson S, Raymond N, Specker S, Eckert E . Increased mortality in bulimia nervosa and other eating disorders. Am J Psychiatry. 2009; 166(12):1342-6. DOI: 10.1176/appi.ajp.2009.09020247. View

Robbins T, Gillan C, Smith D, de Wit S, Ersche K . Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci. 2011; 16(1):81-91. DOI: 10.1016/j.tics.2011.11.009. View

Celone K, Thompson-Brenner H, Ross R, Pratt E, Stern C . An fMRI investigation of the fronto-striatal learning system in women who exhibit eating disorder behaviors. Neuroimage. 2011; 56(3):1749-57. PMC: 3860103. DOI: 10.1016/j.neuroimage.2011.03.026. View

Grilo C, White M, Masheb R . DSM-IV psychiatric disorder comorbidity and its correlates in binge eating disorder. Int J Eat Disord. 2008; 42(3):228-34. PMC: 3666349. DOI: 10.1002/eat.20599. View

10.

Lijffijt M, Bekker E, Quik E, Bakker J, Kenemans J, Verbaten M . Differences between low and high trait impulsivity are not associated with differences in inhibitory motor control. J Atten Disord. 2005; 8(1):25-32. DOI: 10.1177/108705470400800104. View

11.

Bruce K, Koerner N, Steiger H, Young S . Laxative misuse and behavioral disinhibition in bulimia nervosa. Int J Eat Disord. 2002; 33(1):92-7. DOI: 10.1002/eat.10116. View

12.

Claes L, Nederkoorn C, Vandereycken W, Guerrieri R, Vertommen H . Impulsiveness and lack of inhibitory control in eating disorders. Eat Behav. 2006; 7(3):196-203. DOI: 10.1016/j.eatbeh.2006.05.001. View

13.

Van den Eynde F, Guillaume S, Broadbent H, Stahl D, Campbell I, Schmidt U . Neurocognition in bulimic eating disorders: a systematic review. Acta Psychiatr Scand. 2011; 124(2):120-40. DOI: 10.1111/j.1600-0447.2011.01701.x. View

14.

Mobbs O, Iglesias K, Golay A, Van der Linden M . Cognitive deficits in obese persons with and without binge eating disorder. Investigation using a mental flexibility task. Appetite. 2011; 57(1):263-71. DOI: 10.1016/j.appet.2011.04.023. View

15.

Duchesne M, Mattos P, Appolinario J, de Freitas S, Coutinho G, Santos C . Assessment of executive functions in obese individuals with binge eating disorder. Braz J Psychiatry. 2011; 32(4):381-8. DOI: 10.1590/s1516-44462010000400011. View

16.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

17.

Galimberti E, Martoni R, Cavallini M, Erzegovesi S, Bellodi L . Motor inhibition and cognitive flexibility in eating disorder subtypes. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 36(2):307-12. DOI: 10.1016/j.pnpbp.2011.10.017. View

18.

Nigg J . On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy. Psychol Bull. 2000; 126(2):220-46. DOI: 10.1037/0033-2909.126.2.220. View

19.

Wu M, Giel K, Skunde M, Schag K, Rudofsky G, de Zwaan M . Inhibitory control and decision making under risk in bulimia nervosa and binge-eating disorder. Int J Eat Disord. 2013; 46(7):721-8. DOI: 10.1002/eat.22143. View

20.

Aron A, Robbins T, Poldrack R . Inhibition and the right inferior frontal cortex. Trends Cogn Sci. 2004; 8(4):170-7. DOI: 10.1016/j.tics.2004.02.010. View