Neuro-hormonal Effects of Physical Activity in the Elderly

Overview

Journal Front Physiol

Date 2014 Jan 7

PMID 24391595

Citations 7

Authors

Grazia D Femminella

Claudio de Lucia

Paola Iacotucci

Roberto Formisano

Laura Petraglia

Elena Allocca

Enza Ratto

Loreta DAmico

Carlo Rengo

Gennaro Pagano

Domenico Bonaduce

Giuseppe Rengo

Nicola Ferrara

Affiliations

Soon will be listed here.

Abstract

Thanks to diagnostic and therapeutic advances, the elderly population is continuously increasing in the western countries. Accordingly, the prevalence of most chronic age-related diseases will increase considerably in the next decades, thus it will be necessary to implement effective preventive measures to face this epidemiological challenge. Among those, physical activity exerts a crucial role, since it has been proven to reduce the risk of cardiovascular diseases, diabetes, obesity, cognitive impairment and cancer. The favorable effects of exercise on cardiovascular homeostasis can be at least in part ascribed to the modulation of the neuro-hormonal systems implicated in cardiovascular pathophysiology. In the elderly, exercise has been shown to affect catecholamine secretion and biosynthesis, to positively modulate the renin-angiotensin-aldosterone system and to reduce the levels of plasma brain natriuretic peptides. Moreover, drugs modulating the neuro-hormonal systems may favorably affect physical capacity in the elderly. Thus, efforts should be made to actually make physical activity become part of the therapeutic tools in the elderly.

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