The Link Between Acute Kidney Injury and Chronic Kidney Disease

Overview

Journal Curr Opin Nephrol Hypertens

Specialties Cardiology & Vascular Diseases
Nephrology

Date 2014 Jan 4

PMID 24384553

Citations 54

Authors

Linda Y Belayev

Paul M Palevsky

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: It has been argued that the existing epidemiologic data are insufficient to establish a causal link between acute kidney injury (AKI) and subsequent development or progression of chronic kidney disease (CKD), especially given that risk factors for the development of AKI overlap with those for progressive CKD.

Recent Findings: Multiple studies published over the past 5 years have demonstrated a strong epidemiologic association between episodes of AKI and subsequent development or progression of CKD, including evidence that severity of AKI and repeated episodes of AKI are associated with increased risk of CKD. In addition, animal models have provided evidence for a biological basis linking episodes of AKI with CKD.

Summary: The preponderance of data support a causal link between episodes of AKI and subsequent development or progression of CKD.

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References

Wald R, Quinn R, Adhikari N, Burns K, Friedrich J, Garg A . Risk of chronic dialysis and death following acute kidney injury. Am J Med. 2012; 125(6):585-93. DOI: 10.1016/j.amjmed.2012.01.016. View

Hui-Stickle S, Brewer E, Goldstein S . Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. Am J Kidney Dis. 2005; 45(1):96-101. DOI: 10.1053/j.ajkd.2004.09.028. View

Hsu C . Yes, AKI truly leads to CKD. J Am Soc Nephrol. 2012; 23(6):967-9. DOI: 10.1681/ASN.2012030222. View

Bucaloiu I, Kirchner H, Norfolk E, Hartle 2nd J, Perkins R . Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int. 2011; 81(5):477-85. DOI: 10.1038/ki.2011.405. View

Briggs J, Kennedy A, YOUNG L, Luke R, Gray M . Renal function after acute tubular necrosis. Br Med J. 1967; 3(5564):513-6. PMC: 1842895. DOI: 10.1136/bmj.3.5564.513. View

Hill A . THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION?. Proc R Soc Med. 1965; 58:295-300. PMC: 1898525. DOI: 10.1177/003591576505800503. View

Lo L, Go A, Chertow G, McCulloch C, Fan D, Ordonez J . Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int. 2009; 76(8):893-9. PMC: 2771754. DOI: 10.1038/ki.2009.289. View

Amdur R, Chawla L, Amodeo S, Kimmel P, Palant C . Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis. Kidney Int. 2009; 76(10):1089-97. DOI: 10.1038/ki.2009.332. View

Thakar C, Christianson A, Himmelfarb J, Leonard A . Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol. 2011; 6(11):2567-72. PMC: 3359576. DOI: 10.2215/CJN.01120211. View

10.

Schiffl H, Fischer R . Five-year outcomes of severe acute kidney injury requiring renal replacement therapy. Nephrol Dial Transplant. 2008; 23(7):2235-41. DOI: 10.1093/ndt/gfn182. View

11.

Chawla L, Kimmel P . Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int. 2012; 82(5):516-24. DOI: 10.1038/ki.2012.208. View

12.

Heung M, Chawla L . Predicting progression to chronic kidney disease after recovery from acute kidney injury. Curr Opin Nephrol Hypertens. 2012; 21(6):628-34. DOI: 10.1097/MNH.0b013e3283588f24. View

13.

Basile D, Donohoe D, Roethe K, Osborn J . Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. Am J Physiol Renal Physiol. 2001; 281(5):F887-99. DOI: 10.1152/ajprenal.2001.281.5.F887. View

14.

Ishani A, Xue J, Himmelfarb J, Eggers P, Kimmel P, Molitoris B . Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2008; 20(1):223-8. PMC: 2615732. DOI: 10.1681/ASN.2007080837. View

15.

FINKENSTAEDT J, MERRILL J . Renal function after recovery from acute renal failure. N Engl J Med. 1956; 254(22):1023-6. DOI: 10.1056/NEJM195605312542203. View

16.

Ishani A, Nelson D, Clothier B, Schult T, Nugent S, Greer N . The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch Intern Med. 2011; 171(3):226-33. DOI: 10.1001/archinternmed.2010.514. View

17.

Wald R, Quinn R, Luo J, Li P, Scales D, Mamdani M . Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA. 2009; 302(11):1179-85. DOI: 10.1001/jama.2009.1322. View

18.

Rifkin D, Coca S, Kalantar-Zadeh K . Does AKI truly lead to CKD?. J Am Soc Nephrol. 2012; 23(6):979-84. PMC: 3358766. DOI: 10.1681/ASN.2011121185. View

19.

Wang H, Muntner P, Chertow G, Warnock D . Acute kidney injury and mortality in hospitalized patients. Am J Nephrol. 2012; 35(4):349-55. PMC: 3362180. DOI: 10.1159/000337487. View

20.

LOWE K . The late prognosis in acute tubular necrosis; an interim follow-up report on 14 patients. Lancet. 1952; 1(6718):1086-8. DOI: 10.1016/s0140-6736(52)90744-7. View