Serovar D and E of Serogroup B Induce Highest Serological Responses in Urogenital Chlamydia Trachomatis Infections

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2014 Jan 4

PMID 24383586

Citations 6

Authors

Stephan P Verweij

Esmee Lanjouw

Caroline J Bax

Koen D Quint

Paul M Oostvogel

P Joep Dorr

Jolein Pleijster

Henry J C de Vries

Remco P H Peters

Sander Ouburg

Servaas A Morre

Affiliations

Soon will be listed here.

Abstract

Background: Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection (STI) worldwide. A strong link between C. trachomatis serogroup/serovar and serological response has been suggested in a previous preliminary study. The aim of the current study was to confirm and strengthen those findings about serological IgG responses in relation to C. trachomatis serogroups and serovars.

Methods: The study population (n = 718) consisted of two patient groups with similar characteristics of Dutch STI clinic visitors. We performed genotyping of serovars and used titre based and quantitative commercially available ELISA kits (medac Diagnostika) to determine specific serum IgG levels. Optical density (OD) values generated by both tests were used to calculate the IgG titres (cut-off 1:50). Analyses were conducted stratified by gender.

Results: We observed very significant differences when comparing the median IgG titres of three serogroups, B, C and I: in women for B vs. C: p < 0.0001 (median titres B 200 vs. C <50); B vs. I: p < 0.0001 (200 vs. 50), and in men for B vs. C: p = 0.0006 (150 vs. <50); B vs. I: p = 0.0001 (150 vs. <50); C vs. I was not significant for both sexes. Serovars D and E of serogroup B had the highest median IgG titres compared to the other serovars in both men and women: 200 and 200 vs. ≤ 100 for women and 100 and 200 vs. ≤ 75 for men, respectively.

Conclusions: This study shows that B group serovars induce higher serological responses compared to the C and I group serovars in vivo in both men and women.

Citing Articles

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