Coexistence of Hodgkin's Lymphoma and Castleman's Disease: A Case Report with Successful Response to Chemotherapy and Radiotherapy

Overview

Journal Case Rep Oncol Med

Publisher Wiley

Specialty Oncology

Date 2014 Jan 2

PMID 24381772

Citations 6

Authors

Amina Mohtaram

Mohammed Afif

Tanae Sghiri

Amal Rami

Rachida Latib

Fouad Kettani

Meryam Ben Ameur El Youbi

Saber Boutayeb

Tayeb Kebdani

Noureddine Benjaafar

Imane Aaribi

Hassan Errihani

Affiliations

Soon will be listed here.

Abstract

Background. Castleman's disease is a rare clinicopathological entity of unknown origin. Coexistence of Hodgkin's lymphoma and Castleman's disease is rare. We report a case of Hodgkin's disease of cervical lymph nodes in a patient previously diagnosed with Castleman's disease. Case Presentation. A 43-year-old man admitted in July 2009 for a right cervical pain with lymph node at the physician examination. He underwent a right adenectomy and histological studies showed typical features of Castleman's disease. Three years after, the patient consulted for increasing the volume of cervical lymph node. Clinical examination showed a right cervical lymph node of 3 cm. The computed tomography scan of chest, abdominal and pelvic was normal. Histological and immunohistochemical studies of cervical lymph node biopsy specimen were in favor of Castleman's disease associated with Hodgkin's disease. Reed-Sternberg cells were positive for CD15 and CD30. The patient received chemotherapy based on anthracyclines, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy with complete response. Conclusion. Prevalence of Hodgkin's lymphoma in Castleman's disease is more difficult to establish because of the low number of cases reported in the literature.

Citing Articles

Axillary Reactive Lymphoid Hyperplasia, Likely Due to Unicentric Castleman Disease, and the Concurrent Presence of Orbital Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma: A Six-Year Follow-Up Study.

Matsuo T, Tanaka T, Fuji T, Ennishi D Cureus. 2024; 16(11):e73775.

PMID: 39677068 PMC: 11646696. DOI: 10.7759/cureus.73775.

Unmasking Hodgkin's Lymphoma and Its Mimics: Delving into the Interfollicular Zone Beyond Castleman's Disease.

Osama M, Aggarwal A, Mehta N, Sharma P, Rao S Indian J Surg Oncol. 2024; 15(4):699-705.

PMID: 39555358 PMC: 11564489. DOI: 10.1007/s13193-024-01973-3.

Classical Hodgkin Lymphoma on the Background of Castleman Disease: A Case Report.

Makoseh M, Al-Ibraheem A, Almasri N, Hamed E, Alrabi K Cureus. 2023; 15(9):e44930.

PMID: 37818525 PMC: 10561525. DOI: 10.7759/cureus.44930.

Hodgkin Lymphoma-related Inflammatory Modification-displayed Castleman Disease-like Histological Features and Positron Emission Tomography/Computed Tomography Usefulness for the Differential Diagnosis.

Yamauchi H, Momoki M, Kamiyama Y, Gunji T, Yokoyama H, Saito T Intern Med. 2023; 63(7):993-998.

PMID: 37558474 PMC: 11045375. DOI: 10.2169/internalmedicine.2284-23.

Cytology of Castleman's disease (hyaline-vascular type) masquerading as Hodgkin's lymphoma.

Phulware R, Ramteke P, Yadav R, Iyer V, Mallick S Am J Blood Res. 2023; 12(6):196-200.

PMID: 36742279 PMC: 9890186.

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