Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in China

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2014 Jan 1

PMID 24379595

Citations 38

Authors

Su-Wen Li

Kai Wang

Yong-Qiang Yu

Hai-Bao Wang

Yuan-Hai Li

Jian-Ming Xu

Affiliations

Soon will be listed here.

Abstract

Aim: To construct normal values for the tests of the psychometric hepatic encephalopathy score (PHES) and to evaluate its usefulness in the diagnosis of minimal hepatic encephalopathy (MHE) among Chinese individuals with cirrhosis.

Methods: The five tests of PHES, number connection test-A (NCT-A), number connection test-B, serial dotting test, line tracing test and digit symbol test (DST), were administered to all enrolled subjects in a quiet room with sufficient light. Cirrhotic subjects with overt HE were excluded by the West-Haven criteria and a detailed neurological examination. Based on the nomograms of healthy volunteers, the patients were classified as having MHE when their PHES was less than -4.

Results: In total, 146 healthy volunteers completed all the PHES tests. Age and education years were confirmed to be predictors of all five tests. In total, 53 patients with liver cirrhosis completed the PHES. Of the patients with liver cirrhosis, 24 (45.3%), 22(41.5%) and 7(13.2%) had Child-Pugh grades A, B and C, respectively. MHE was diagnosed in 26 patients (49.1%). Compared with compensated cirrhotic patients (Child A), decompensated cirrhotic patients (Child B and C) had a higher proportion of MHE (65.5% vs 29.2%). No differences in age and education years were found between the MHE and non-MHE groups. NCT-A and DST were able to diagnose MHE with a sensitivity of 76.9% and a specificity of 96.3% (AUC = 0.866, K = 0.735).

Conclusion: The proportion of MHE is associated with liver function. NCT-A and DST are simple tools that can be used for the diagnosis of MHE in China.

Citing Articles

Psychometric Hepatic Encephalopathy Tests and Electroencephalogram Results Among Cirrhotic Patients.

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The crucial role of risk factors when dealing with hepatic Encephalopathy.

Lapenna L, Di Cola S, Merli M Metab Brain Dis. 2024; 40(1):29.

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Correlation of ammonia and blood laboratory parameters with hepatic encephalopathy: A systematic review and meta-analysis.

Sepehrinezhad A, Moghaddam N, Shayan N, Negah S PLoS One. 2024; 19(9):e0307899.

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Portosystemic Hepatic Encephalopathy Scores (PHES) differ between Danish and German healthy populations despite their geographical and cultural similarities.

Lauridsen M, Gronkjaer L, Atkins J, Mikkelsen S, Svensson T, Kimer N Metab Brain Dis. 2024; 39(6):1149-1155.

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Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop-CN model (NCRCID-CHESS 2106): a prospective multicenter study.

Li X, Liu S, Guo Y, Zu H, Xiang H, Yang S MedComm (2020). 2024; 5(8):e627.

PMID: 39015557 PMC: 11247336. DOI: 10.1002/mco2.627.

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