Possible Relations Between Oxidative Damage and Apoptosis in Benign Prostate Hyperplasia and Prostate Cancer Patients

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Dec 31

PMID 24375255

Citations 11

Authors

Funda Kosova

Gokhan Temeltas

Zeki Ari

Murat Lekili

Affiliations

Soon will be listed here.

Abstract

Cancer has been described as the twentieth century plague, and is a very common health problem. It has been reported that ROS and ROS products play a key role in cancer and that oxidative damage is effective in apoptosis initiation. In this study we aimed to evaluate the relationship between MDA (malondialdehyde), DNA damage (8-hydroxyguanine, 8-OH-dG), and caspase-3 in BHP and prostate cancer patients. Twenty male patients with prostate cancer and 20 male patients with benign prostate hyperplasia were included into this study. The MDA (nanomole), DNA damage (nanograms per millilitre), and caspase-3 (nanograms per millilitre) levels were measured in prostate cancer and benign prostate hyperplasia using Elisa kits (Millipore Corporation, Billerica, MA, USA). In the prostate cancer group, serum MDA (30.96 ± 9.25) and DNA damage (4.42 ± 0.36) levels were significantly raised (p < 0.05) when compared to the benign prostate hyperplasia group (24.05 ± 8.06, 3.99 ± 0.54). However, in the prostate cancer group, serum caspase-3 (2.36 ± 0.82) levels were statistically significantly lowered (p < 0.05) compared with the benign prostate hyperplasia group (3.15 ± 1.04). We observed that altered prooxidant, DNA damage levels may lead to an increase in oxidative damage and may consequently play an important role in prostate carcinogenesis. These findings indicate that, although the triggering of these changes is unknown, changes in the levels of MDA, DNA damage, and caspase-3 in the blood are related to prostatic carcinoma development. In addition, it would be appropriate to conduct new studies with a large number of patients at different stages.

Citing Articles

8-Hydroxy-2-Deoxyguanosine and 8-Iso-Prostaglandin F2α: Putative Biomarkers to assess Oxidative Stress Damage Following Robot-Assisted Radical Prostatectomy (RARP).

Di Minno A, Aveta A, Gelzo M, Tripodi L, Pandolfo S, Crocetto F J Clin Med. 2022; 11(20).

PMID: 36294423 PMC: 9605140. DOI: 10.3390/jcm11206102.

L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation.

Elsherbini D, Almohaimeed H, El-Sherbiny M, Mohammedsaleh Z, Elsherbiny N, Gabr S Antioxidants (Basel). 2022; 11(6).

PMID: 35740046 PMC: 9219805. DOI: 10.3390/antiox11061149.

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment.

Neganova M, Liu J, Aleksandrova Y, Klochkov S, Fan R Cancers (Basel). 2021; 13(23).

PMID: 34885171 PMC: 8657135. DOI: 10.3390/cancers13236062.

Oxidative Stress and Antioxidant Status in High-Risk Prostate Cancer Subjects.

Shukla S, Srivastava J, Shankar E, Kanwal R, Nawab A, Sharma H Diagnostics (Basel). 2020; 10(3).

PMID: 32120827 PMC: 7151307. DOI: 10.3390/diagnostics10030126.

The Oxygen Paradox, the French Paradox, and age-related diseases.

Davies J, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R Geroscience. 2017; 39(5-6):499-550.

PMID: 29270905 PMC: 5745211. DOI: 10.1007/s11357-017-0002-y.

References

Gao K, Henning S, Niu Y, Youssefian A, Seeram N, Xu A . The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. J Nutr Biochem. 2005; 17(2):89-95. DOI: 10.1016/j.jnutbio.2005.05.009. View

Fenech M, Ferguson L . Vitamins/minerals and genomic stability in humans. Mutat Res. 2001; 475(1-2):1-6. DOI: 10.1016/s0027-5107(01)00069-0. View

Chen H, Chang F, Hsieh Y, Cheng Y, Hsieh K, Tsai L . A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. Free Radic Biol Med. 2011; 50(9):1151-62. DOI: 10.1016/j.freeradbiomed.2011.01.015. View

Valko M, Rhodes C, Moncol J, Izakovic M, Mazur M . Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006; 160(1):1-40. DOI: 10.1016/j.cbi.2005.12.009. View

Hockenbery D, Oltvai Z, Yin X, Milliman C, Korsmeyer S . Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 1993; 75(2):241-51. DOI: 10.1016/0092-8674(93)80066-n. View

DMello S . Molecular regulation of neuronal apoptosis. Curr Top Dev Biol. 1998; 39:187-213. DOI: 10.1016/s0070-2153(08)60456-1. View

Stadtman E, Berlett B . Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev. 1998; 30(2):225-43. DOI: 10.3109/03602539808996310. View

Wang J, Yi J . Cancer cell killing via ROS: to increase or decrease, that is the question. Cancer Biol Ther. 2008; 7(12):1875-84. DOI: 10.4161/cbt.7.12.7067. View

Greenlund L, Deckwerth T, Johnson Jr E . Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron. 1995; 14(2):303-15. DOI: 10.1016/0896-6273(95)90287-2. View

10.

Mihara M, Uchiyama M . Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978; 86(1):271-8. DOI: 10.1016/0003-2697(78)90342-1. View

11.

Na H, Oliynyk S . Effects of physical activity on cancer prevention. Ann N Y Acad Sci. 2011; 1229:176-83. DOI: 10.1111/j.1749-6632.2011.06105.x. View

12.

Malins D, Johnson P, Wheeler T, Barker E, Polissar N, Vinson M . Age-related radical-induced DNA damage is linked to prostate cancer. Cancer Res. 2001; 61(16):6025-8. View

13.

Arsova-Sarafinovska Z, Eken A, Matevska N, Erdem O, Sayal A, Savaser A . Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer. Clin Biochem. 2009; 42(12):1228-35. DOI: 10.1016/j.clinbiochem.2009.05.009. View

14.

Koka P, Mondal D, Schultz M, Abdel-Mageed A, Agrawal K . Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exp Biol Med (Maywood). 2010; 235(6):751-60. DOI: 10.1258/ebm.2010.009369. View

15.

Pace G, Di Massimo C, De Amicis D, Corbacelli C, Di Renzo L, Vicentini C . Oxidative stress in benign prostatic hyperplasia and prostate cancer. Urol Int. 2010; 85(3):328-33. DOI: 10.1159/000315064. View

16.

Forsberg L, de Faire U, Morgenstern R . Oxidative stress, human genetic variation, and disease. Arch Biochem Biophys. 2001; 389(1):84-93. DOI: 10.1006/abbi.2001.2295. View

17.

Matsuzawa A, Ichijo H . Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal. 2005; 7(3-4):472-81. DOI: 10.1089/ars.2005.7.472. View

18.

Czene K, Lichtenstein P, Hemminki K . Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database. Int J Cancer. 2002; 99(2):260-6. DOI: 10.1002/ijc.10332. View

19.

Guzel S, Kiziler L, Aydemir B, Alici B, Ataus S, Aksu A . Association of Pb, Cd, and Se concentrations and oxidative damage-related markers in different grades of prostate carcinoma. Biol Trace Elem Res. 2011; 145(1):23-32. DOI: 10.1007/s12011-011-9162-2. View

20.

Kroemer G, Zamzami N, Susin S . Mitochondrial control of apoptosis. Immunol Today. 1997; 18(1):44-51. DOI: 10.1016/s0167-5699(97)80014-x. View