Nickel and Chromium Levels in the Saliva of a Saudi Sample Treated with Fixed Orthodontic Appliances

Overview

Journal Saudi Dent J

Specialty Dentistry

Date 2013 Dec 28

PMID 24371378

Citations 5

Authors

Nabeel F Talic

Hasan H Alnahwi

Ali S Al-Faraj

Affiliations

Soon will be listed here.

Abstract

Aim: The aim of this study was to measure the amount of nickel (Ni) and chromium (Cr) released into the saliva of Saudi patients treated with fixed orthodontic appliances.

Materials And Methods: Ninety salivary samples were collected in a cross-sectional manner. Forty samples were collected from patients (17 males, 23 females) with fixed orthodontic appliances after different periods of orthodontic treatment ranging from the first month and up to 32 months into treatment. The fixed orthodontic appliance consisted of 4 bands, 20 stainless steel brackets, and upper and lower nickel titanium or stainless-steel arch wires. The other 50 samples were collected from people without appliances (24 males, 26 females). Samples were analyzed using Inductive Coupled Plasma/Mass Spectrometry and Inductively Coupled Plasma Optical Emission Spectroscopy to measure Ni and Cr levels, respectively. Student's t-test was used to compare Ni and Cr levels in the treated and untreated control groups.

Results: The mean Ni level was 4.197 μg/L in the experimental group and 2.3 μg/L in the control group (p < 0.05). The mean Cr level was 2.9 μg/L in the experimental group and 3.3 μg/L in the control group (p < 0.05).

Conclusion: Fixed orthodontic appliances resulted in a non-toxic increase in salivary levels of Ni, but no change in Cr levels. Duration of orthodontic treatment did not affect Ni and Cr levels in the saliva.

Citing Articles

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Biomonitorization of metal ions in the serum of Iranian patients treated with fixed orthodontic appliances in comparison with controls in eastern Iran.

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Effect of Fixed Orthodontic Treatment on Salivary Nickel and Chromium Levels: A Systematic Review and Meta-Analysis of Observational Studies.

Imani M, Mozaffari H, Ramezani M, Sadeghi M Dent J (Basel). 2019; 7(1).

PMID: 30823648 PMC: 6473672. DOI: 10.3390/dj7010021.

Salivary Electrolytes in Patients with Metallic and Ceramic Orthodontic Brackets.

Jurela A, Verzak Z, Brailo V, Skrinjar I, Sudarevic K, Jankovic B Acta Stomatol Croat. 2018; 52(1):32-36.

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References

Barceloux D . Nickel. J Toxicol Clin Toxicol. 1999; 37(2):239-58. DOI: 10.1081/clt-100102423. View

Kerosuo H, Moe G, Kleven E . In vitro release of nickel and chromium from different types of simulated orthodontic appliances. Angle Orthod. 1995; 65(2):111-6. DOI: 10.1043/0003-3219(1995)065<0111:IVRONA>2.0.CO;2. View

Menezes L, Quintao C, Bolognese A . Urinary excretion levels of nickel in orthodontic patients. Am J Orthod Dentofacial Orthop. 2007; 131(5):635-8. DOI: 10.1016/j.ajodo.2005.07.022. View

Stenman E, Bergman M . Hypersensitivity reactions to dental materials in a referred group of patients. Scand J Dent Res. 1989; 97(1):76-83. DOI: 10.1111/j.1600-0722.1989.tb01433.x. View

Toms A . The corrosion of orthodontic wire. Eur J Orthod. 1988; 10(2):87-97. DOI: 10.1093/ejo/10.2.87. View

Park H, Shearer T . In vitro release of nickel and chromium from simulated orthodontic appliances. Am J Orthod. 1983; 84(2):156-9. DOI: 10.1016/0002-9416(83)90180-x. View

Kim H, Johnson J . Corrosion of stainless steel, nickel-titanium, coated nickel-titanium, and titanium orthodontic wires. Angle Orthod. 1999; 69(1):39-44. DOI: 10.1043/0003-3219(1999)069<0039:COSSNT>2.3.CO;2. View

Kerosuo H, Kullaa A, Kerosuo E, Kanerva L . Nickel allergy in adolescents in relation to orthodontic treatment and piercing of ears. Am J Orthod Dentofacial Orthop. 1996; 109(2):148-54. DOI: 10.1016/s0889-5406(96)70175-0. View

Jia W, Beatty M, Reinhardt R, Petro T, Cohen D, Maze C . Nickel release from orthodontic arch wires and cellular immune response to various nickel concentrations. J Biomed Mater Res. 1999; 48(4):488-95. DOI: 10.1002/(sici)1097-4636(1999)48:4<488::aid-jbm14>3.0.co;2-d. View

10.

. A study of nickel allergy. J Prosthet Dent. 1984; 52(1):116-9. DOI: 10.1016/0022-3913(84)90193-8. View

11.

Platt J, Guzman A, ZUCCARI A, Thornburg D, Rhodes B, Oshida Y . Corrosion behavior of 2205 duplex stainless steel. Am J Orthod Dentofacial Orthop. 1997; 112(1):69-79. DOI: 10.1016/s0889-5406(97)70276-2. View

12.

Agaoglu G, Arun T, Izgi B, Yarat A, Izgu B . Nickel and chromium levels in the saliva and serum of patients with fixed orthodontic appliances. Angle Orthod. 2001; 71(5):375-9. DOI: 10.1043/0003-3219(2001)071<0375:NACLIT>2.0.CO;2. View

13.

Fors R, Stenberg B, Stenlund H, Persson M . Nickel allergy in relation to piercing and orthodontic appliances--a population study. Contact Dermatitis. 2012; 67(6):342-50. DOI: 10.1111/j.1600-0536.2012.02097.x. View

14.

Barrett R, Bishara S, Quinn J . Biodegradation of orthodontic appliances. Part I. Biodegradation of nickel and chromium in vitro. Am J Orthod Dentofacial Orthop. 1993; 103(1):8-14. DOI: 10.1016/0889-5406(93)70098-9. View

15.

Grimsdottir M, Gjerdet N . Composition and in vitro corrosion of orthodontic appliances. Am J Orthod Dentofacial Orthop. 1992; 101(6):525-32. DOI: 10.1016/0889-5406(92)70127-V. View

16.

Setcos J, Babaei-Mahani A, Di Silvio L, Mjor I, Wilson N . The safety of nickel containing dental alloys. Dent Mater. 2006; 22(12):1163-8. DOI: 10.1016/j.dental.2005.11.033. View

17.

Singh D, Sehgal V, Pradhan K, Chandna A, Gupta R . Estimation of nickel and chromium in saliva of patients with fixed orthodontic appliances. World J Orthod. 2008; 9(3):196-202. View

18.

RAHILLY G, Price N . Nickel allergy and orthodontics. J Orthod. 2003; 30(2):171-4. DOI: 10.1093/ortho/30.2.171. View

19.

Jones T, Hansen C, Singer M, Kessler H . Dental implications of nickel hypersensitivity. J Prosthet Dent. 1986; 56(4):507-9. DOI: 10.1016/0022-3913(86)90398-7. View

20.

NORSETH T . The carcinogenicity of chromium. Environ Health Perspect. 1981; 40:121-30. PMC: 1568823. DOI: 10.1289/ehp.8140121. View