Human Genetics of Diabetic Vascular Complications

Overview

Journal J Genet

Specialty Genetics

Date 2013 Dec 28

PMID 24371189

Citations 5

Authors

Zi-Hui Tang

Zhou Fang

Linuo Zhou

Affiliations

Soon will be listed here.

Abstract

Diabetic vascular complications (DVC) affecting several important organ systems of human body such as the cardiovascular system constitute a major public health problem. There is evidence demonstrating that genetic factors contribute to the risk of DVC genetic variants, structural variants, and epigenetic changes play important roles in the development of DVC. Genetic linkage studies have uncovered a number of genetic loci that may shape the risk of DVC. Genetic association studies have identified many common genetic variants for susceptibility to DVC. Structural variants such as copy number variation and interactions of gene x environment have also been detected by association analysis. Apart from the nuclear genome, mitochondrial DNA plays a critical role in regulation of development of DVC. Epigenetic studies have indicated epigenetic changes in chromatin affecting gene transcription in response to environmental stimuli, which provided a large body of evidence of regulating development of diabetes mellitus. Recently, a new window has opened on identifying rare and common genetic loci through next generation sequencing technologies. This review focusses on the current knowledge of the genetic and epigenetic basis of DVC. Ultimately, identification of genes or genetic loci, structural variants and epigenetic changes contributing to risk of or protection from DVC will help uncover the complex mechanism(s) underlying DVC, with crucial implications for the development of personalized medicine for diabetes mellitus and its complications.

Citing Articles

Type 1 Diabetes Mellitus: Cellular and Molecular Pathophysiology at A Glance.

Saberzadeh-Ardestani B, Karamzadeh R, Basiri M, Hajizadeh-Saffar E, Farhadi A, Shapiro A Cell J. 2018; 20(3):294-301.

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c.*84G>A Mutation in CETP Is Associated with Coronary Artery Disease in South Indians.

Ganesan M, Nizamuddin S, Katkam S, Kumaraswami K, Hosad U, Lobo L PLoS One. 2016; 11(10):e0164151.

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Identifying Common Genetic Risk Factors of Diabetic Neuropathies.

Witzel I, Jelinek H, Khalaf K, Lee S, Khandoker A, AlSafar H Front Endocrinol (Lausanne). 2015; 6:88.

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Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes.

Prattichizzo F, Giuliani A, Ceka A, Rippo M, Bonfigli A, Testa R Clin Epigenetics. 2015; 7:56.

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Interleukin-10-1082A/G polymorphism and diabetic nephropathy: a meta-analysis.

Peng X, Xu J, Wang P, Zhou J, Guo H Med Sci Monit. 2015; 21:890-4.

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