Immune Therapeutic Strategies in Chronic Hepatitis B Virus Infection: Virus or Inflammation Control?

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2013 Dec 25

PMID 24367255

Citations 31

Authors

Antonio Bertoletti

Adam J Gehring

Affiliations

Soon will be listed here.

Citing Articles

Insights into Immune Exhaustion in Chronic Hepatitis B: A Review of Checkpoint Receptor Expression.

Costa J, de Carvalho A, Paiva A, Borges O Pharmaceuticals (Basel). 2024; 17(7).

PMID: 39065812 PMC: 11279883. DOI: 10.3390/ph17070964.

Development of a highly potent anti-HBs monoclonal antibody for HBV and HDV therapy: An improvement with unsettled questions.

Mouzannar K, Liang T J Hepatol. 2023; 79(5):1079-1081.

PMID: 37586647 PMC: 11653528. DOI: 10.1016/j.jhep.2023.08.002.

Development of Chimeric Hepatitis B (HBV) - Norovirus (NoV) P particle as candidate vaccine against Hepatitis B and norovirus infection.

Giri-Rachman E, Tan M, Ramesh A, Fajar P, Nurul Ilmi A, Retnoningrum D Vaccine X. 2023; 14:100354.

PMID: 37519778 PMC: 10372314. DOI: 10.1016/j.jvacx.2023.100354.

Host Factors in the Natural History of Chronic Hepatitis B: Role of Genetic Determinants.

Turyadi , Witanto B, El-Khobar K, Parewangi M, Rasyak M, Wibowo D Int J Hepatol. 2022; 2022:6046677.

PMID: 36052277 PMC: 9427277. DOI: 10.1155/2022/6046677.

Immune therapies against chronic hepatitis B.

Akbar S, Yoshida O, Hiasa Y J Gastroenterol. 2022; 57(8):517-528.

PMID: 35708793 PMC: 9308615. DOI: 10.1007/s00535-022-01890-8.

References

Xu D, Wang X, Shen X, Gong G, Ren H, Guo L . Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings. J Hepatol. 2013; 59(3):450-6. DOI: 10.1016/j.jhep.2013.05.003. View

Das A, Hoare M, Davies N, Lopes A, Dunn C, Kennedy P . Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. J Exp Med. 2008; 205(9):2111-24. PMC: 2526205. DOI: 10.1084/jem.20072076. View

Michel M, Deng Q, Mancini-Bourgine M . Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: perspectives and challenges. J Hepatol. 2011; 54(6):1286-96. DOI: 10.1016/j.jhep.2010.12.031. View

Gehring A, Haniffa M, Kennedy P, Ho Z, Boni C, Shin A . Mobilizing monocytes to cross-present circulating viral antigen in chronic infection. J Clin Invest. 2013; 123(9):3766-76. PMC: 3754243. DOI: 10.1172/JCI66043. View

Nebbia G, Peppa D, Schurich A, Khanna P, Singh H, Cheng Y . Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLoS One. 2012; 7(10):e47648. PMC: 3480425. DOI: 10.1371/journal.pone.0047648. View

Lutgehetmann M, Bornscheuer T, Volz T, Allweiss L, Bockmann J, Pollok J . Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice. Gastroenterology. 2011; 140(7):2074-83, 2083.e1-2. DOI: 10.1053/j.gastro.2011.02.057. View

Maini M, Schurich A . The molecular basis of the failed immune response in chronic HBV: therapeutic implications. J Hepatol. 2010; 52(4):616-9. DOI: 10.1016/j.jhep.2009.12.017. View

Micco L, Peppa D, Loggi E, Schurich A, Jefferson L, Cursaro C . Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B. J Hepatol. 2012; 58(2):225-33. DOI: 10.1016/j.jhep.2012.09.029. View

Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A . Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012; 18(7):1060-8. PMC: 3478098. DOI: 10.1038/nm.2811. View

10.

Tang X, Jo J, Tan A, Sandalova E, Chia A, Tan K . IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol. 2013; 190(7):3142-52. DOI: 10.4049/jimmunol.1203218. View

11.

Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N . A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet. 2009; 41(5):591-5. DOI: 10.1038/ng.348. View

12.

Bertoletti A, Ferrari C . Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut. 2011; 61(12):1754-64. DOI: 10.1136/gutjnl-2011-301073. View

13.

Kennedy P, Sandalova E, Jo J, Gill U, Ushiro-Lumb I, Tan A . Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B. Gastroenterology. 2012; 143(3):637-645. DOI: 10.1053/j.gastro.2012.06.009. View

14.

Schurich A, Pallett L, Lubowiecki M, Singh H, Gill U, Kennedy P . The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells. PLoS Pathog. 2013; 9(3):e1003208. PMC: 3597507. DOI: 10.1371/journal.ppat.1003208. View

15.

Schurich A, Khanna P, Lopes A, Han K, Peppa D, Micco L . Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection. Hepatology. 2011; 53(5):1494-503. DOI: 10.1002/hep.24249. View

16.

Kosinska A, Zhang E, Johrden L, Liu J, Seiz P, Zhang X . Combination of DNA prime--adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model. PLoS Pathog. 2013; 9(6):e1003391. PMC: 3681757. DOI: 10.1371/journal.ppat.1003391. View

17.

Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F . Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci U S A. 2012; 109(32):E2165-72. PMC: 3420192. DOI: 10.1073/pnas.1209182109. View

18.

Krebs K, Bottinger N, Huang L, Chmielewski M, Arzberger S, Gasteiger G . T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice. Gastroenterology. 2013; 145(2):456-65. DOI: 10.1053/j.gastro.2013.04.047. View

19.

Schietinger A, Delrow J, Basom R, Blattman J, Greenberg P . Rescued tolerant CD8 T cells are preprogrammed to reestablish the tolerant state. Science. 2012; 335(6069):723-7. PMC: 3754789. DOI: 10.1126/science.1214277. View

20.

Raziorrouh B, Schraut W, Gerlach T, Nowack D, Gruner N, Ulsenheimer A . The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function. Hepatology. 2010; 52(6):1934-47. DOI: 10.1002/hep.23936. View