Aurora B Kinase in Hodgkin Lymphoma: Immunohistochemical Pattern of Expression in Neoplastic Hodgkin and Reed-Sternberg Cells

Overview

Journal J Mol Histol

Specialty Biochemistry

Date 2013 Dec 25

PMID 24366835

Citations 4

Authors

M Ioannou

E Kouvaras

E Stathakis

M Samara

G K Koukoulis

Affiliations

Soon will be listed here.

Abstract

Aurora B is a member of the chromosomal passenger complex, which is essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge there are extremely limited studies investigating the immunohistochemical expression of Aurora B in tumor specimens of Hodgkin lymphoma. Our purpose was to characterize the expression of Aurora B in biopsies of Hodgkin lymphomas, and to evaluate the pattern of immunoreactivity in neoplastic Hodgkin and Reed-Sternberg cells (RS cells). We examined Aurora B immunoreactivity in paraffin sections of 15 samples of Hodgkin lymphomas, obtained from 15 patients, 8 men and 7 women. Ten were of nodular sclerosis type and five were of mixed cellularity. Our results showed immunoexpression of Aurora B in mononuclear lymphoid cells as well as in bi- and multinucleated RS cells. In addition, positive neoplastic cells in mitosis were observed, whereas a subpopulation without evidence of immunoreaction was also detected in each case. Taken together our results point to a possible association between Aurora B expression and mitotic deregulation in Hodgkin lymphoma, which may provide novel targets for treatment.

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References

MKacher R, Girinsky T, Koscielny S, Dossou J, Violot D, Beron-Gaillard N . Baseline and treatment-induced chromosomal abnormalities in peripheral blood lymphocytes of Hodgkin's lymphoma patients. Int J Radiat Oncol Biol Phys. 2003; 57(2):321-6. DOI: 10.1016/s0360-3016(03)00578-9. View

Leoncini L, Megha T, Lazzi S, Bellan C, Luzi P, Tosi P . Cellular kinetic differences between Hodgkin's and anaplastic large cell lymphomas: relation to the expression of p34cdc2 and cyclin B-1. Int J Cancer. 1998; 77(3):408-14. DOI: 10.1002/(sici)1097-0215(19980729)77:3<408::aid-ijc17>3.0.co;2-3. View

Steigemann P, Wurzenberger C, Schmitz M, Held M, Guizetti J, Maar S . Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 2009; 136(3):473-84. DOI: 10.1016/j.cell.2008.12.020. View

Martin-Subero J, Knippschild U, Harder L, Barth T, Riemke J, Grohmann S . Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma?. Leukemia. 2003; 17(11):2214-9. DOI: 10.1038/sj.leu.2403129. View

Lee E, Frolov A, Li R, Ayala G, Greenberg N . Targeting Aurora kinases for the treatment of prostate cancer. Cancer Res. 2006; 66(10):4996-5002. DOI: 10.1158/0008-5472.CAN-05-2796. View

Leoncini L, Spina D, Megha T, Gallorini M, Tosi P, Hummel M . Cell kinetics, morphology, and molecular IgVH gene rearrangements in Hodgkin's disease. Leuk Lymphoma. 1997; 26(3-4):307-16. DOI: 10.3109/10428199709051780. View

Carmena M . Abscission checkpoint control: stuck in the middle with Aurora B. Open Biol. 2012; 2(7):120095. PMC: 3411112. DOI: 10.1098/rsob.120095. View

Krem M, Horwitz M . Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma pathogenesis. Commun Integr Biol. 2013; 6(3):e23544. PMC: 3656006. DOI: 10.4161/cib.23544. View

Campo E, Swerdlow S, Harris N, Pileri S, Stein H, Jaffe E . The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011; 117(19):5019-32. PMC: 3109529. DOI: 10.1182/blood-2011-01-293050. View

10.

Lordier L, Chang Y, Jalil A, Aurade F, Garcon L, Lecluse Y . Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process. Blood. 2010; 116(13):2345-55. DOI: 10.1182/blood-2010-01-265785. View

11.

Mishima M, Kaitna S, Glotzer M . Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev Cell. 2002; 2(1):41-54. DOI: 10.1016/s1534-5807(01)00110-1. View

12.

Kadin M, Asbury A . Long term cultures of Hodgkin's tissue. A morphologic and radioautographic study. Lab Invest. 1973; 28(2):181-4. View

13.

Mori N, Ishikawa C, Senba M, Kimura M, Okano Y . Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt's and Hodgkin's lymphomas. Biochem Pharmacol. 2011; 81(9):1106-15. DOI: 10.1016/j.bcp.2011.02.010. View

14.

Tatsuka M, Katayama H, Ota T, Tanaka T, ODASHIMA S, Suzuki F . Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res. 1998; 58(21):4811-6. View

15.

Kuppers R, Brauninger A, Muschen M, Distler V, Hansmann M, Rajewsky K . Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood. 2001; 97(3):818-21. DOI: 10.1182/blood.v97.3.818. View

16.

Barbanis S, Ioannou M, Kouvaras E, Karasavvidou F, Nakou M, Papamichali R . INCENP (inner centromere protein) is overexpressed in high grade non-Hodgkin B-cell lymphomas. Pathol Oncol Res. 2008; 15(1):11-7. DOI: 10.1007/s12253-008-9094-0. View

17.

Nguyen H, Ravid K . Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins. J Cell Physiol. 2005; 208(1):12-22. DOI: 10.1002/jcp.20565. View

18.

van der Waal M, Hengeveld R, van der Horst A, Lens S . Cell division control by the Chromosomal Passenger Complex. Exp Cell Res. 2012; 318(12):1407-20. DOI: 10.1016/j.yexcr.2012.03.015. View

19.

Adams R, CARMENA M, Earnshaw W . Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol. 2001; 11(2):49-54. DOI: 10.1016/s0962-8924(00)01880-8. View

20.

Anastasi J, Bauer K, Variakojis D . DNA aneuploidy in Hodgkin's disease. A multiparameter flow-cytometric analysis with cytologic correlation. Am J Pathol. 1987; 128(3):573-82. PMC: 1899678. View