Calcium Channel Blockers in Reduction of Epidural Fibrosis and Dural Adhesions in Laminectomy Rats

Overview

Journal Eur J Orthop Surg Traumatol

Specialty Orthopedics

Date 2013 Dec 25

PMID 24366378

Citations 9

Authors

Zhiqiang Wang

Yuguang Wang

Peng Xie

Wei Liu

Sai Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the effect of verapamil on the prevention of epidural fibrosis in laminectomy rats.

Methods: A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. All rats were divided randomly into three groups according to the treatment method, with 20 in each group: (1) VP treatment group; (2) vehicle treatment group; and (3) sham group (laminectomy without treatment). All rats were killed 4 weeks post-laminectomy. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density and inflammatory factors expressions were evaluated.

Results: The histological evaluation showed less epidural scar adhesions in verapamil group than other two groups. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density and inflammatory factors expressions all suggested better results in verapamil group than other two groups.

Conclusion: Topical application of verapamil could inhibit fibroblasts proliferation and TGF-β1 and IL-6 expressions and prevent epidural scar adhesion in post-laminectomy rat model.

Citing Articles

Postoperative Epidural Fibrosis: Challenges and Opportunities - A Review.

Lewik G, Lewik G, Muller L, von Glinski A, Schulte T, Lange T Spine Surg Relat Res. 2024; 8(2):133-142.

PMID: 38618214 PMC: 11007250. DOI: 10.22603/ssrr.2023-0106.

Pharmacotherapies to prevent epidural fibrosis after laminectomy: a systematic review of in vitro and in vivo animal models.

Ganesh V, Kancherla Y, Igram C, Pugely A, Salem A, Shin K Spine J. 2023; 23(10):1471-1484.

PMID: 37187251 PMC: 10538436. DOI: 10.1016/j.spinee.2023.05.007.

Comparison of the effect of bipolar coagulation and fibrillar structured oxidized cellulose on formation epidural fibrosis in rats.

Cetin E, Eren B, Karagoz Guzey F, Tufan A, Tas A, Ornek M Turk J Med Sci. 2021; 51(4):2206-2212.

PMID: 33984889 PMC: 8569783. DOI: 10.3906/sag-2002-162.

EFFECT OF PLATELET-RICH PLASMA, FAT PAD AND DURAL MATRIX IN PREVENTING EPIDURAL FIBROSIS.

Guler S, Akcali O, Sen B, Cilaker Micili S, Sanli N, Cankaya D Acta Ortop Bras. 2020; 28(1):31-35.

PMID: 32095110 PMC: 7006529. DOI: 10.1590/1413-785220202801218823.

Intra-articular injection of mitomycin C prevents progression of immobilization-induced arthrogenic contracture in the remobilized rat knee.

Kaneguchi A, Ozawa J, Yamaoka K Physiol Res. 2019; 69(1):145-156.

PMID: 31852201 PMC: 8565959. DOI: 10.33549/physiolres.934149.

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