Lineage Specific Antigenic Differences in Porcine Torovirus Hemagglutinin-esterase (PToV-HE) Protein

Overview

Journal Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2013 Dec 25

PMID 24364900

Citations 3

Authors

Jaime Pignatelli

Julio Alonso-Padilla

Dolores Rodriguez

Affiliations

Soon will be listed here.

Abstract

Hemagglutinin-esterases (HE) are viral envelope proteins present in some members from the toro-, corona- and orthomyxovirus families, all related with enteric and/or respiratory tract infections. HE proteins mediate reversible binding to sialic acid receptor determinants, very abundant glycan residues in the enteric and respiratory tracts. The role of the HE protein during the torovirus infection cycle remains unknown, although it is believed to be important in the natural infection process. The phylogenetic analysis of HE coding sequences from porcine torovirus (PToV) field strains revealed the existence of two distinct HE lineages. In a previous study, PToV virus strains with HE proteins from the two lineages were found coexisting in a pig herd, and they were even obtained from the same animal at two consecutive sampling time points. In this work, we report antigenic differences between the two HE lineages, and discuss the possible implications that the coexistence of viruses belonging to both lineages might have on the spread and sustainment of PToV infection in the farms.

Citing Articles

Recent Progress in Torovirus Molecular Biology.

Ujike M, Taguchi F Viruses. 2021; 13(3).

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Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication.

Avila-Perez G, Diaz-Beneitez E, Cubas-Gaona L, Nieves-Molina G, Rodriguez J, Rodriguez J PLoS One. 2019; 14(7):e0219428.

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Porcine Torovirus (PToV)-A Brief Review of Etiology, Diagnostic Assays and Current Epidemiology.

Hu Z, Yang Y, Xu L, Wang B, Qin P, Huang Y Front Vet Sci. 2019; 6:120.

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