Glucocorticosteroid in Treatment of Severe Pneumonia

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2013 Dec 24

PMID 24363503

Citations 11

Authors

Felinda Ariani

Kaixiong Liu

Zhang Jing

Jieming Qu

Affiliations

Soon will be listed here.

Abstract

Airway diseases such as pneumonia constitute a major health burden on a global scale; untreated pneumonia may develop to severe pneumonia and consequently lead to to fatal episodes of mortality and morbidity. The balance between inflammatory mediators is key for the outcome of the pulmonary infection; elimination of invading pathogen was marked by the release of cytokines and other inflammatory mediators from alveolar macrophages and glucocorticoid steroids (GCs) acting on the inflammatory component. Treatments of severe pneumonia with GCs have been developing for years with inconclusive results. In many cases GCs have been administered empirically without clinical evidence. Recent studies assess beneficial impact on treatment of severe pneumonia by suggesting specific dosage, period of administration, and tapered dosage.

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References

Ho J, Ooi G, Mok T, Chan J, Hung I, Lam B . High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome. Am J Respir Crit Care Med. 2003; 168(12):1449-56. DOI: 10.1164/rccm.200306-766OC. View

Marik P, Kraus P, Sribante J, Havlik I, Lipman J, Johnson D . Hydrocortisone and tumor necrosis factor in severe community-acquired pneumonia. A randomized controlled study. Chest. 1993; 104(2):389-92. DOI: 10.1378/chest.104.2.389. View

Meduri G, Golden E, Freire A, Taylor E, Zaman M, Carson S . Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest. 2007; 131(4):954-63. DOI: 10.1378/chest.06-2100. View

Annane D, Cavaillon J . Corticosteroids in sepsis: from bench to bedside?. Shock. 2003; 20(3):197-207. DOI: 10.1097/01.shk.0000079423.72656.2f. View

Monton C, Torres A, Filella X, Xaubet A, de la Bellacasa J . Cytokine expression in severe pneumonia: a bronchoalveolar lavage study. Crit Care Med. 1999; 27(9):1745-53. DOI: 10.1097/00003246-199909000-00008. View

Yale S, Limper A . Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy. Mayo Clin Proc. 1996; 71(1):5-13. DOI: 10.4065/71.1.5. View

Hien N, Ha N, Van N, Ha N, Lien T, Thai N . Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004-2005. Emerg Infect Dis. 2009; 15(1):19-23. PMC: 2660684. DOI: 10.3201/eid1501.080073. View

Kaufmann I, Briegel J, Schliephake F, Hoelzl A, Chouker A, Hummel T . Stress doses of hydrocortisone in septic shock: beneficial effects on opsonization-dependent neutrophil functions. Intensive Care Med. 2007; 34(2):344-9. DOI: 10.1007/s00134-007-0868-8. View

Fernandez-Serrano S, Dorca J, Garcia-Vidal C, Fernandez-Sabe N, Carratala J, Fernandez-Aguera A . Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial. Crit Care. 2011; 15(2):R96. PMC: 3219361. DOI: 10.1186/cc10103. View

10.

Sprung C, Annane D, Keh D, Moreno R, Singer M, Freivogel K . Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008; 358(2):111-24. DOI: 10.1056/NEJMoa071366. View

11.

Vogel M, Vatlach M, Weissgerber P, Goeppert B, Claussen C, Hetzel J . HRCT-features of Pneumocystis jiroveci pneumonia and their evolution before and after treatment in non-HIV immunocompromised patients. Eur J Radiol. 2011; 81(6):1315-20. DOI: 10.1016/j.ejrad.2011.02.052. View

12.

Annane D, Bellissant E, Bollaert P, Briegel J, Keh D, Kupfer Y . Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ. 2004; 329(7464):480. PMC: 515196. DOI: 10.1136/bmj.38181.482222.55. View

13.

Oppert M, Schindler R, Husung C, Offermann K, Graf K, Boenisch O . Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med. 2005; 33(11):2457-64. DOI: 10.1097/01.ccm.0000186370.78639.23. View

14.

Kil H, Lee J, Lee K, Rhim J, Youn Y, Kang J . Early corticosteroid treatment for severe pneumonia caused by 2009 H1N1 influenza virus. Crit Care. 2011; 15(2):413. PMC: 3219342. DOI: 10.1186/cc10082. View

15.

Salluh J, Povoa P, Soares M, Castro-Faria-Neto H, Bozza F, Bozza P . The role of corticosteroids in severe community-acquired pneumonia: a systematic review. Crit Care. 2008; 12(3):R76. PMC: 2481473. DOI: 10.1186/cc6922. View

16.

McGee S, Hirschmann J . Use of corticosteroids in treating infectious diseases. Arch Intern Med. 2008; 168(10):1034-46. DOI: 10.1001/archinte.168.10.1034. View

17.

Amado-Rodriguez L, Gonzalez-Lopez A, Lopez-Alonso I, Aguirre A, Astudillo A, Batalla-Solis E . Anti-inflammatory effects of clarithromycin in ventilator-induced lung injury. Respir Res. 2013; 14:52. PMC: 3667083. DOI: 10.1186/1465-9921-14-52. View

18.

Mesotten D, Vanhorebeek I, Van den Berghe G . The altered adrenal axis and treatment with glucocorticoids during critical illness. Nat Clin Pract Endocrinol Metab. 2008; 4(9):496-505. DOI: 10.1038/ncpendmet0921. View

19.

Stockman L, Bellamy R, Garner P . SARS: systematic review of treatment effects. PLoS Med. 2006; 3(9):e343. PMC: 1564166. DOI: 10.1371/journal.pmed.0030343. View

20.

Ware L, Matthay M . The acute respiratory distress syndrome. N Engl J Med. 2000; 342(18):1334-49. DOI: 10.1056/NEJM200005043421806. View