» Articles » PMID: 24356378

Gap Junction Signalling is a Stress-regulated Component of Adrenal Neuroendocrine Stimulus-secretion Coupling in Vivo

Overview
Journal Nat Commun
Specialty Biology
Date 2013 Dec 21
PMID 24356378
Citations 21
Authors
Affiliations
Soon will be listed here.
Abstract

Elucidating the mechanisms whereby neuroendocrine tissues coordinate their input and output signals to ensure appropriate hormone secretion is currently a topical issue. In particular, whether a direct communication mediated by gap junctions between neurosecretory cells contributes to hormone release in vivo still remains unknown. Here we address this issue using a microsurgical approach allowing combined monitoring of adrenal catecholamine secretion and splanchnic nerve stimulation in anaesthetised mice. Pharmacological blockade of adrenal gap junctions by the uncoupling agent carbenoxolone reduces nerve stimulation-evoked catecholamine release in control mice and to a larger extent in stressed mice. In parallel, the gap junction-coupled cell network is extended in stressed mice. Altogether, this argues for a significant contribution of adrenomedullary gap junctions to catecholamine secretion in vivo. As such, gap junctional signalling appears to be a substantial component for neuroendocrine function in the adrenal medulla, as it may represent an additional lever regulating hormone release.

Citing Articles

Multilevel Stressors and Systemic and Tumor Immunity in Black and White Women With Breast Cancer.

Harris A, Pichardo C, Franklin J, Liu H, Wooten W, Panigrahi G JAMA Netw Open. 2025; 8(2):e2459754.

PMID: 39951265 PMC: 11829235. DOI: 10.1001/jamanetworkopen.2024.59754.


Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment.

Paille V, Park J, Toutain B, Bourreau J, Fontanaud P, De Nardi F Cell Mol Life Sci. 2024; 82(1):31.

PMID: 39725761 PMC: 11671677. DOI: 10.1007/s00018-024-05524-5.


The Role of the Gap Junction Protein Connexin in Adrenal Gland Tumorigenesis.

Mizdrak M, Kurir T, Mizdrak I, Kumric M, Krnic M, Bozic J Int J Mol Sci. 2024; 25(10).

PMID: 38791437 PMC: 11121959. DOI: 10.3390/ijms25105399.


Two firing modes and well-resolved Na, K, and Ca currents at the cell-microelectrode junction of spontaneously active rat chromaffin cell on MEAs.

Marcantoni A, Chiantia G, Tomagra G, Hidisoglu E, Franchino C, Carabelli V Pflugers Arch. 2022; 475(2):181-202.

PMID: 36260174 PMC: 9849155. DOI: 10.1007/s00424-022-02761-0.


Basal and Stress-Induced Network Activity in the Adrenal Medulla .

Lopez Ruiz J, Ernst S, Holz R, Stuenkel E Front Endocrinol (Lausanne). 2022; 13:875865.

PMID: 35795145 PMC: 9250985. DOI: 10.3389/fendo.2022.875865.