Two-component Systems in Streptomyces: Key Regulators of Antibiotic Complex Pathways

Overview

Journal Microb Cell Fact

Publisher Biomed Central

Specialties Biotechnology
Microbiology

Date 2013 Dec 21

PMID 24354561

Citations 41

Authors

Hector Rodriguez

Sergio Rico

Margarita Diaz

Ramon I Santamaria

Affiliations

Soon will be listed here.

Abstract

Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary "sensing" device.Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production.

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