The Common Causes Leading to Pancytopenia in Patients Presenting to Tertiary Care Hospital

Overview

Journal Pak J Med Sci

Specialty General Medicine

Date 2013 Dec 20

PMID 24353701

Citations 18

Authors

Kirpal Das Makheja

Bharat Kumar Maheshwari

Shafique Arain

Suneel Kumar

Sangeeta Kumari

Vikash

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to determine the frequency of common causes leading to Pancytopenia in patients presenting to tertiary care hospital at Karachi.

Methods: A total of 62 patients with the diagnosis of Pancytopenia of more than one week duration were enrolled in the study. All patients underwent a detailed medical history and full physical examination followed by blood sampling for the investigations i.e. complete blood count with peripheral film, erythrocyte sedimentation rate (ESR), Malarial parasites (MP), liver function test, Renal function tests, PT and viral profile (HBsAg, Anti-HCV), Ultrasonography of abdomen. All patients underwent bone marrow aspiration and trephine biopsy for reporting and interpretation. Duration of study was six months, from May 2010 to November 2010.

Results: The average age of the patients was 37.76 ± 16.38years. Out of 62 patients, 36 (58%) were male and 26 (42%) were female. Megaloblastic anemia was the commonest cause that was observed in 41.9% cases followed by acute myeloid leukemia 27.4%, aplastic anemia 19.4% and erythroid hyperplasia 11.3%. Conclusion : This study concluded that most common cause of pancytopenia is Megaloblastic anemia, followed by acute myeloid leukemia and aplastic anemia. Bone marrow examination is a single useful investigation which reveals the underlying cause in patients with pancytopenia.

Citing Articles

Trimethoprim-Sulfamethoxazole-Induced Pancytopenia: A Case Report.

Chahal J, Junko G Cureus. 2025; 16(12):e75113.

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Etiological Spectrum of Bone Marrow Biopsy in Patients With Pancytopenia.

Ullah I, Khan D, Qureshi V Cureus. 2024; 16(11):e73138.

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A Comprehensive Analysis of Clinical Presentations, Laboratory Findings, and Etiologies of Pancytopenia: A Tertiary Care Experience.

Fazal W, Khan S, Akhtar R, Khattak S, Ali M, Kakakhel M Cureus. 2024; 16(11):e73148.

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Pancytopenia in Carbamazepine Therapy: A Rare and Serious Entity with Simple Prevention.

Bhardwaj A, Prakash R, Gupta D, Jose N Int J Appl Basic Med Res. 2023; 13(1):44-46.

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A Challenging Diagnosis of Febrile Pancytopenia in a Patient With a History of Autoimmune Disease.

Guevara N, Flores Chang M, Castelar J, Sequeira H, Berger J Cureus. 2023; 15(3):e35956.

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