Immunosuppression of the Trimellitic Anhydride-induced Th2 Response by Novel Nonanatural Products Mixture in Mice

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2013 Dec 19

PMID 24348718

Authors

Min-Jung Bae

Hee Soon Shin

Dong-Hwa Shon

Affiliations

Soon will be listed here.

Abstract

Many natural dietary products prevent or cure allergic inflammation; however, the ability of mixtures of these natural medicinals to suppress allergic skin inflammation is unknown. We examined the inhibitory effects of nonanatural products mixture (NPM-9), which provides immunoregulatory activation, on Th2-mediated skin allergic inflammation. Oral administration of NPM-9 in mice reduced ear thickness and specific IgE production in trimellitic anhydride- (TMA-)induced contact hypersensitivity (CHS). NPM-9 also suppressed IL-4 and IL-1β production in splenocytes but prevented only TMA-induced IL-1β production in inflamed ears. To characterize the mechanism of this effect, we examined NPM-9 immunosuppression on an OVA-induced Th2 allergic state. Oral administration of NPM-9 inhibited Th2-mediated serum IgE overproduction. NPM-9 also downregulated the polarized Th2 response, whereas it upregulated Th1 response in splenocytes. These data suggest that NPM-9 may be a useful therapeutic agent for allergic inflammatory diseases through its suppression of the Th2-mediated allergic response.

References

Kotani M, Matsumoto M, Fujita A, HIGA S, Wang W, Suemura M . Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol. 2000; 106(1 Pt 1):159-66. DOI: 10.1067/mai.2000.107194. View

Youn H, Lee J, Saitoh S, Miyake K, Kang K, Choi Y . Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem Pharmacol. 2006; 72(7):850-9. DOI: 10.1016/j.bcp.2006.06.021. View

Zhai L, Li Y, Wang W, Wang Y, Hu S . Effect of oral administration of ginseng stem-and-leaf saponins (GSLS) on the immune responses to Newcastle disease vaccine in chickens. Vaccine. 2011; 29(31):5007-14. DOI: 10.1016/j.vaccine.2011.04.097. View

Chen L, Martinez O, Overbergh L, Mathieu C, Prabhakar B, Chan L . Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model. Clin Exp Immunol. 2004; 138(3):375-87. PMC: 1809236. DOI: 10.1111/j.1365-2249.2004.02649.x. View

Mandegary A, Pournamdari M, Sharififar F, Pournourmohammadi S, Fardiar R, Shooli S . Alkaloid and flavonoid rich fractions of fenugreek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects. Food Chem Toxicol. 2012; 50(7):2503-7. DOI: 10.1016/j.fct.2012.04.020. View

Carter L, Dutton R . Type 1 and type 2: a fundamental dichotomy for all T-cell subsets. Curr Opin Immunol. 1996; 8(3):336-42. DOI: 10.1016/s0952-7915(96)80122-1. View

Koo J, Arain S . Traditional Chinese medicine for the treatment of dermatologic disorders. Arch Dermatol. 1998; 134(11):1388-93. DOI: 10.1001/archderm.134.11.1388. View

Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr H . Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet. 2003; 361(9374):2045-6. PMC: 7112442. DOI: 10.1016/s0140-6736(03)13615-x. View

Kim J, Oh S, Kwon H, Oh Y, Lim S, Shin H . Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biochem Biophys Res Commun. 2006; 345(3):1215-23. DOI: 10.1016/j.bbrc.2006.05.035. View

10.

Teran L . TARC: novel mediator of allergic inflammation. Clin Exp Allergy. 2001; 31(12):1809-12. DOI: 10.1046/j.1365-2222.2001.01268.x. View

11.

Sailstad D, Ward M, Boykin E, Selgrade M . A murine model for low molecular weight chemicals: differentiation of respiratory sensitizers (TMA) from contact sensitizers (DNFB). Toxicology. 2003; 194(1-2):147-61. DOI: 10.1016/s0300-483x(03)00338-x. View

12.

Fujimura Y, Umeda D, Yano S, Maeda-Yamamoto M, Yamada K, Tachibana H . The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG. Biochem Biophys Res Commun. 2007; 364(1):79-85. DOI: 10.1016/j.bbrc.2007.09.095. View

13.

Leung D, Soter N . Cellular and immunologic mechanisms in atopic dermatitis. J Am Acad Dermatol. 2001; 44(1 Suppl):S1-S12. DOI: 10.1067/mjd.2001.109815. View

14.

Dai J, Iwatani Y, Ishida T, Terunuma H, Kasai H, Iwakula Y . Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Immunology. 2001; 103(2):235-43. PMC: 1783229. DOI: 10.1046/j.1365-2567.2001.01224.x. View

15.

Spergel J, Mizoguchi E, Oettgen H, Bhan A, Geha R . Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest. 1999; 103(8):1103-11. PMC: 408277. DOI: 10.1172/JCI5669. View

16.

Majdalawieh A, Carr R . In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum). J Med Food. 2010; 13(2):371-81. DOI: 10.1089/jmf.2009.1131. View

17.

Kim G, Kim K, Lee S, Yoon M, Lee H, Moon D . Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol. 2005; 174(12):8116-24. DOI: 10.4049/jimmunol.174.12.8116. View

18.

Yoon S, Lee Y, Park S, Kim H, Bae H, Kim H . Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. J Ethnopharmacol. 2009; 125(2):286-90. DOI: 10.1016/j.jep.2009.06.027. View

19.

Galli S, Tsai M, Piliponsky A . The development of allergic inflammation. Nature. 2008; 454(7203):445-54. PMC: 3573758. DOI: 10.1038/nature07204. View

20.

Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S . Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol. 2003; 3(2):257-65. DOI: 10.1016/S1567-5769(02)00292-8. View