The Perinucleolar Compartment Associates with Malignancy

Overview

Journal Front Biol (Beijing)

Specialty Biology

Date 2013 Dec 19

PMID 24348523

Citations 8

Authors

Yiping Wen

Chen Wang

Sui Huang

Affiliations

Soon will be listed here.

Abstract

The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both and . PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.

Citing Articles

Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis.

Kashyap V, Sharma B, Pandey D, Singh A, Peasah-Darkwah G, Singh B Cells. 2025; 13(24.

PMID: 39768145 PMC: 11674295. DOI: 10.3390/cells13242053.

Polypyrimidine Tract Binding Protein: A Universal Player in Cancer Development.

Gonzalez E, Flatt T, Farooqi M, Johnson L, Ahmed A Curr Mol Med. 2023; 24(12):1450-1460.

PMID: 37877563 DOI: 10.2174/0115665240251370231017053236.

K-Homology Type Splicing Regulatory Protein: Mechanism of Action in Cancer and Immune Disorders.

Leavenworth J, Yusuf N, Hassan Q Crit Rev Eukaryot Gene Expr. 2023; 34(1):75-87.

PMID: 37824394 PMC: 11003564. DOI: 10.1615/CritRevEukaryotGeneExpr.2023048085.

Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study.

Gonzalez E, Ahmed A, McCarthy L, Chastain K, Habeebu S, Zapata-Tarres M Cancers (Basel). 2023; 15(8).

PMID: 37190159 PMC: 10136508. DOI: 10.3390/cancers15082230.

Safety assessment of metarrestin in dogs: A clinical candidate targeting a subnuclear structure unique to metastatic cancer cells.

Bourdi M, Rudloff U, Patnaik S, Marugan J, Terse P Regul Toxicol Pharmacol. 2020; 116:104716.

PMID: 32619635 PMC: 8378239. DOI: 10.1016/j.yrtph.2020.104716.

References

Kaminski A, Hunt S, Patton J, Jackson R . Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA. RNA. 1995; 1(9):924-38. PMC: 1369341. View

Frank R, Hargreaves R . Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov. 2003; 2(7):566-80. DOI: 10.1038/nrd1130. View

Perederina A, Esakova O, Quan C, Khanova E, Krasilnikov A . Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain. EMBO J. 2010; 29(4):761-9. PMC: 2829168. DOI: 10.1038/emboj.2009.396. View

Pollock C, Daily K, Nguyen V, Wang C, Lewandowska M, Bensaude O . Characterization of MRP RNA-protein interactions within the perinucleolar compartment. Mol Biol Cell. 2011; 22(6):858-67. PMC: 3057709. DOI: 10.1091/mbc.E10-09-0768. View

Xie J, Lee J, Kress T, Mowry K, Black D . Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein. Proc Natl Acad Sci U S A. 2003; 100(15):8776-81. PMC: 166389. DOI: 10.1073/pnas.1432696100. View

Lee B, Matera A, Ward D, Craft J . Association of RNase mitochondrial RNA processing enzyme with ribonuclease P in higher ordered structures in the nucleolus: a possible coordinate role in ribosome biogenesis. Proc Natl Acad Sci U S A. 1996; 93(21):11471-6. PMC: 38081. DOI: 10.1073/pnas.93.21.11471. View

Esakova O, Krasilnikov A . Of proteins and RNA: the RNase P/MRP family. RNA. 2010; 16(9):1725-47. PMC: 2924533. DOI: 10.1261/rna.2214510. View

Hall M, Huang S, Black D . Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA. Mol Biol Cell. 2003; 15(2):774-86. PMC: 329392. DOI: 10.1091/mbc.e03-09-0692. View

Ho T, Bundman D, Armstrong D, Cooper T . Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy. Hum Mol Genet. 2005; 14(11):1539-47. DOI: 10.1093/hmg/ddi162. View

10.

Fox A, Lamond A . Paraspeckles. Cold Spring Harb Perspect Biol. 2010; 2(7):a000687. PMC: 2890200. DOI: 10.1101/cshperspect.a000687. View

11.

Hellen C, Pestova T, Litterst M, Wimmer E . The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region. J Virol. 1994; 68(2):941-50. PMC: 236532. DOI: 10.1128/JVI.68.2.941-950.1994. View

12.

Pettaway C, Pathak S, Greene G, Ramirez E, Wilson M, Killion J . Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res. 1996; 2(9):1627-36. View

13.

Zwerger M, Ho C, Lammerding J . Nuclear mechanics in disease. Annu Rev Biomed Eng. 2011; 13:397-428. PMC: 4600467. DOI: 10.1146/annurev-bioeng-071910-124736. View

14.

OKeefe R, Mayeda A, Sadowski C, Krainer A, Spector D . Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol. 1994; 124(3):249-60. PMC: 2119927. DOI: 10.1083/jcb.124.3.249. View

15.

Wang C, Politz J, Pederson T, Huang S . RNA polymerase III transcripts and the PTB protein are essential for the integrity of the perinucleolar compartment. Mol Biol Cell. 2003; 14(6):2425-35. PMC: 194890. DOI: 10.1091/mbc.e02-12-0818. View

16.

Altman S . Ribonuclease P. Postscript. J Biol Chem. 1990; 265(33):20053-6. View

17.

Savkur R, Philips A, Cooper T . Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet. 2001; 29(1):40-7. DOI: 10.1038/ng704. View

18.

Pickering B, Mitchell S, Evans J, Willis A . Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo. Nucleic Acids Res. 2003; 31(2):639-46. PMC: 140511. DOI: 10.1093/nar/gkg146. View

19.

Lou H, Helfman D, Gagel R, Berget S . Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol. 1998; 19(1):78-85. PMC: 83867. DOI: 10.1128/MCB.19.1.78. View

20.

Clayton D . A nuclear function for RNase MRP. Proc Natl Acad Sci U S A. 1994; 91(11):4615-7. PMC: 43837. DOI: 10.1073/pnas.91.11.4615. View