Stem Cells Supporting Other Stem Cells

Overview

Journal Front Genet

Date 2013 Dec 19

PMID 24348512

Citations 21

Authors

Judith Leatherman

Affiliations

Soon will be listed here.

Abstract

Adult stem cell therapies are increasingly prevalent for the treatment of damaged or diseased tissues, but most of the improvements observed to date are attributed to the ability of stem cells to produce paracrine factors that have a trophic effect on existing tissue cells, improving their functional capacity. It is now clear that this ability to produce trophic factors is a normal and necessary function for some stem cell populations. In vivo adult stem cells are thought to self-renew due to local signals from the microenvironment where they live, the niche. Several niches have now been identified which harbor multiple stem cell populations. In three of these niches - the Drosophila testis, the bulge of the mammalian hair follicle, and the mammalian bone marrow - one type of stem cell has been found to produce factors that contribute to the maintenance of a second stem cell population in the shared niche. In this review, I will examine the architecture of these three niches and discuss the molecular signals involved. Together, these examples establish a new paradigm for stem cell behavior, that stem cells can promote the maintenance of other stem cells.

Citing Articles

Development of a + Cardiac Mouse Progenitor Immortalized Model to Unravel the Relationship with Its Protective Vascular Endothelial Niche.

Albericio G, Higuera M, Araque P, Sanchez C, Herrero D, Garcia-Brenes M Int J Mol Sci. 2024; 25(16).

PMID: 39201501 PMC: 11354400. DOI: 10.3390/ijms25168815.

The Drosophila histone methyltransferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation.

Vidaurre V, Song A, Li T, Ku W, Zhao K, Qian J Development. 2024; 151(15).

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Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in testes somatic support cells.

Rinehart L, Stewart W, Luffman N, Wawersik M, Kerscher O PeerJ. 2024; 12:e16971.

PMID: 38495765 PMC: 10944633. DOI: 10.7717/peerj.16971.

The histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation.

Vidaurre V, Song A, Li T, Ku W, Zhao K, Qian J bioRxiv. 2024; .

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Differentiation of Human Wharton Jelly Mesenchymal Stem Cells into Germ-Like Cells; emphasis on evaluation of Germ-long non-coding RNAs.

Ghasemi S, Shafiee M, Ferns G, Tavakol-Afshari J, Saeedi M, Raji S Mol Biol Rep. 2022; 49(12):11901-11912.

PMID: 36241921 DOI: 10.1007/s11033-022-07961-6.

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