Haptoglobin Phenotype and Abnormal Uterine Artery Doppler in a Racially Diverse Cohort

Overview

Journal J Matern Fetal Neonatal Med

Publisher Informa Healthcare

Specialty Gynecology & Obstetrics

Date 2013 Dec 19

PMID 24345080

Authors

Tracey L Weissgerber

Paula L McGee

Leslie Myatt

John C Hauth

Michael W Varner

Ronald J Wapner

John M Thorp Jr

Brian M Mercer

Alan M Peaceman

Susan M Ramin

Philip Samuels

Anthony C Sciscione

Margaret Harper

George Saade

Yoram Sorokin

Affiliations

Soon will be listed here.

Abstract

Objective: The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy.

Methods: We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks' gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups.

Results: Hp phenotype did not significantly influence the odds of having any notch (p = 0.32), bilateral notches (p = 0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks' gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p = 0.25).

Conclusions: Hp phenotype is not associated with abnormal UAD at 17 weeks' gestation or with persistent notching at 24 weeks.

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