Prognostic Value of Matrix Metalloproteinase-7 Expression in Patients with Non-small Cell Lung Cancer

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Dec 17

PMID 24338766

Citations 6

Authors

Yonggang Liang

Shanxian Guo

Qinghua Zhou

Affiliations

Soon will be listed here.

Abstract

The prognostic value of matrix metalloproteinase-7 (MMP-7) for survival of patients with non-small cell lung cancer (NSCLC) remains controversial. We performed a meta-analysis of the literatures to clarify its impact. Trials were selected for meta-analysis if they provided an independent assessment of MMP-7 in NSCLC and reported the analysis of survival data based on MMP-7 status. Pooled hazard ratio (HR) with 95% confidence interval (95% CI) was used to evaluate the associations between MMP-7 expression and survival of NSCLC patients. Heterogeneity and publication bias were also assessed. Seven studies involving 1,446 patients were identified. The combined HR for all studies was 1.28 (95% CI 0.86-1.91; P = 0.22). Subgroup analysis revealed that MMP-7 overexpression had a favorable impact on survival in Caucasians (HR = 0.74; 95% CI 0.55-0.99; P = 0.043) but showed a poor survival prognosis in Asians (HR = 1.74; 95% CI 1.05-2.88, P = 0.031). Its effect also appeared significant when the analysis was restricted to Asian patients with squamous cell cancer (HR =3.42; 95% CI 1.92-6.11, P = 0.000) and adenocarcinoma (HR = 2.1; 95% CI 1.34-3.29, P = 0.001). Our meta-analysis suggests that there are ethnic differences in the clinical significance of MMP-7 expression for patients with NSCLC.

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References

Lee K, Shin S, Kim K, Kim M, Hyun M, Kim T . Relationship between E-cadherin, matrix metalloproteinase-7 gene expression and clinicopathological features in gastric carcinoma. Oncol Rep. 2006; 16(4):823-30. View

Sternlicht M, Werb Z . How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001; 17:463-516. PMC: 2792593. DOI: 10.1146/annurev.cellbio.17.1.463. View

Begg C, Mazumdar M . Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994; 50(4):1088-101. View

Rasheed S, Efferth T, Asangani I, Allgayer H . First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. Int J Cancer. 2010; 127(6):1475-85. DOI: 10.1002/ijc.25315. View

Huang C, Liu D, Ishikawa S, Nakashima T, Nakashima N, Yokomise H . Wnt1 overexpression promotes tumour progression in non-small cell lung cancer. Eur J Cancer. 2008; 44(17):2680-8. DOI: 10.1016/j.ejca.2008.08.004. View

Yamamoto T, Oshima T, Yoshihara K, Nishi T, Arai H, Inui K . Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer. Exp Ther Med. 2012; 3(5):797-802. PMC: 3438550. DOI: 10.3892/etm.2012.493. View

Yue W, Sun Q, Landreneau R, Wu C, Siegfried J, Yu J . Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression. Cancer Res. 2009; 69(15):6339-46. PMC: 2719681. DOI: 10.1158/0008-5472.CAN-09-0398. View

Svatek R, Shah J, Xing J, Chang D, Lin J, McConkey D . A multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer. Cancer. 2010; 116(19):4513-9. DOI: 10.1002/cncr.25401. View

Shieh J, Cheng T, Shi M, Wu P, Chen Y, Ko S . α-Tomatine suppresses invasion and migration of human non-small cell lung cancer NCI-H460 cells through inactivating FAK/PI3K/Akt signaling pathway and reducing binding activity of NF-κB. Cell Biochem Biophys. 2011; 60(3):297-310. DOI: 10.1007/s12013-011-9152-1. View

10.

Tanioka Y, Yoshida T, Yagawa T, Saiki Y, Takeo S, Harada T . Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer. Br J Cancer. 2003; 89(11):2116-21. PMC: 2376843. DOI: 10.1038/sj.bjc.6601372. View

11.

Wang W, Chen P, Wang H, Liang W, Su Y . Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma. Carcinogenesis. 2006; 27(5):1113-20. DOI: 10.1093/carcin/bgi351. View

12.

Zhang S, Wang Y, Dai S, Wang E . Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. BMC Cancer. 2011; 11:186. PMC: 3118196. DOI: 10.1186/1471-2407-11-186. View

13.

Martinez-Fernandez A, Garcia-Albeniz X, Pineda E, Visa L, Gallego R, Codony-Servat J . Serum matrilysin levels predict outcome in curatively resected colorectal cancer patients. Ann Surg Oncol. 2009; 16(5):1412-20. DOI: 10.1245/s10434-009-0405-9. View

14.

Woessner Jr J, Taplin C . Purification and properties of a small latent matrix metalloproteinase of the rat uterus. J Biol Chem. 1988; 263(32):16918-25. View

15.

Mitsiades N, Yu W, Poulaki V, Tsokos M, Stamenkovic I . Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity. Cancer Res. 2001; 61(2):577-81. View

16.

Leinonen T, Pirinen R, Bohm J, Johansson R, Ropponen K, Kosma V . Expression of matrix metalloproteinases 7 and 9 in non-small cell lung cancer. Relation to clinicopathological factors, beta-catenin and prognosis. Lung Cancer. 2006; 51(3):313-21. DOI: 10.1016/j.lungcan.2005.11.002. View

17.

Szarvas T, Becker M, Vom Dorp F, Meschede J, Scherag A, Bankfalvi A . Elevated serum matrix metalloproteinase 7 levels predict poor prognosis after radical prostatectomy. Int J Cancer. 2010; 128(6):1486-92. DOI: 10.1002/ijc.25454. View

18.

Szarvas T, Laszlo V, Vom Dorp F, Reis H, Szendroi A, Romics I . Serum endostatin levels correlate with enhanced extracellular matrix degradation and poor patients' prognosis in bladder cancer. Int J Cancer. 2011; 130(12):2922-9. DOI: 10.1002/ijc.26343. View

19.

Qian Q, Wang Q, Zhan P, Peng L, Wei S, Shi Y . The role of matrix metalloproteinase 2 on the survival of patients with non-small cell lung cancer: a systematic review with meta-analysis. Cancer Invest. 2010; 28(6):661-9. DOI: 10.3109/07357901003735634. View

20.

Yonemura Y, Endo Y, Fujita H, Kimura K, Sugiyama K, Momiyama N . Inhibition of peritoneal dissemination in human gastric cancer by MMP-7-specific antisense oligonucleotide. J Exp Clin Cancer Res. 2001; 20(2):205-12. View