Serum IGF-1 Levels As a Clinical Tool for Optimizing Orthodontic Treatment Timing

Overview

Journal Prog Orthod

Publisher Springer

Specialty Dentistry

Date 2013 Dec 12

PMID 24326183

Citations 8

Authors

Sapna Jain

Sandhya Jain

Anuradha Deoskar

V S Sai Prasad

Affiliations

Soon will be listed here.

Abstract

Background: The study aims to associate serum insulin-like growth factor-1 (IGF-1) levels with cervical maturation stages (CS) 3, 4, and 5 on lateral cephalogram in male subjects and to find out peak serum IGF-1 levels among these three stages.

Methods: The study was conducted on 45 male subjects who were at skeletal maturation stage CS-3, CS-4, and CS-5. Subjects were selected using simple random sampling technique. Serum IGF-1 levels were estimated from blood samples using chemiluminescence immunoassay (CLIA) method. CS was evaluated using a six-stage method of evaluating the cervical vertebrae. Mean IGF-1 levels between the stages were compared by analysis of variance (ANOVA) test.

Results: One-way ANOVA showed highly significant differences between all cervical stages with p value<0.01, but post hoc Tukey test showed highly significant differences between CS-4 and CS-5 with p value 0.006. Serum IGF-1 levels showed good association with skeletal age in male subjects; 53.3% of subjects at CS-3, 66.7% subjects at CS-4, and 6.7% subjects at CS-5 showed IGF-1 levels in peak range.

Conclusions: Serum IGF levels can be used as an additional tool to optimize orthodontic treatment timing.

Citing Articles

Biomarkers in Body Fluids as Indicators of Skeletal Maturity: A Systematic Review and Meta-analysis.

Kapoor P, Balachandran R, Chowdhry A, Perinetti G, Kharbanda O Rambam Maimonides Med J. 2023; 14(4).

PMID: 37669407 PMC: 10619988. DOI: 10.5041/RMMJ.10506.

Association of Salivary IGF and IGF/IGFBP-3 Molar Ratio with Cervical Vertebral Maturation Stages from Pre-Adolescent to Post-Adolescent Transition Period-A Cross-Sectional Exploratory Study.

Almalki A Int J Environ Res Public Health. 2022; 19(9).

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Correlation between Salivary Levels of IGF-1, IGFBP-3, IGF-1/IGFBP3 Ratio with Skeletal Maturity Using Hand-Wrist Radiographs.

Almalki A, Thomas J, Khan A, Almulhim B, Alassaf A, Alghamdi S Int J Environ Res Public Health. 2022; 19(6).

PMID: 35329407 PMC: 8953114. DOI: 10.3390/ijerph19063723.

Correlation between Insulin-Like Growth Factor I and Skeletal Maturity Indicators.

Carelli J, Mattos C, Morais N, Scariot R, Brancher J, Baratto-Filho F Glob Pediatr Health. 2021; 8:2333794X211011305.

PMID: 34017903 PMC: 8114260. DOI: 10.1177/2333794X211011305.

Serum DHEA-S levels could be used as a comparable diagnostic test to assess the pubertal growth spurt in dentofacial orthopedics.

Anusuya V, Nagar A, Tandon P, Singh G, Singh G, Mahdi A Prog Orthod. 2020; 21(1):15.

PMID: 32566987 PMC: 7306481. DOI: 10.1186/s40510-020-00317-5.

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