MRI Stem Cell Tracking for Therapy in Experimental Cerebral Ischemia

Overview

Journal Transl Stroke Res

Publisher Springer

Date 2013 Dec 11

PMID 24323753

Citations 6

Authors

Pedro Ramos-Cabrer

Mathias Hoehn

Affiliations

Soon will be listed here.

Abstract

Magnetic resonance has an established role in investigations on the evolution of stroke and the assessment of therapeutic strategies in experimental animals. Here we show that the technique has also an important place for the study of stem cell-mediated regenerative therapies after stroke. We review the literature by bridging from the methodological aspects of stem cell labeling via grafting and monitoring of cell dynamics after implantation into the brain all the way to MRI's role in analyzing the stem cell-mediated functional improvement. Thus, we have aimed at a view combining the focus on the monitoring of the cell activities with the aspect of lesion evolution while including also the essence of a potential functional improvement by the implantation of stem cells following stroke.

Citing Articles

Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke.

Helsper S, Yuan X, Bagdasarian F, Athey J, Li Y, Borlongan C Transl Stroke Res. 2022; 14(4):545-561.

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In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease.

Glover J, Aswendt M, Boulland J, Lojk J, Stamenkovic S, Andjus P Mol Imaging Biol. 2019; 22(6):1469-1488.

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Cell tracking technologies for acute ischemic brain injury.

Gavins F, Smith H J Cereb Blood Flow Metab. 2015; 35(7):1090-9.

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Magnetic resonance imaging of transplanted stem cell fate in stroke.

Aghayan H, Soleimani M, Goodarzi P, Norouzi-Javidan A, Emami-Razavi S, Larijani B J Res Med Sci. 2014; 19(5):465-71.

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References

Wei L, Cui L, Snider B, Rivkin M, Yu S, Lee C . Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. Neurobiol Dis. 2005; 19(1-2):183-93. DOI: 10.1016/j.nbd.2004.12.016. View

Srinivas M, Morel P, Ernst L, Laidlaw D, Ahrens E . Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model. Magn Reson Med. 2007; 58(4):725-34. DOI: 10.1002/mrm.21352. View

Kustermann E, Himmelreich U, Kandal K, Geelen T, Ketkar A, Wiedermann D . Efficient stem cell labeling for MRI studies. Contrast Media Mol Imaging. 2008; 3(1):27-37. DOI: 10.1002/cmmi.229. View

Cormode D, Jarzyna P, Mulder W, Fayad Z . Modified natural nanoparticles as contrast agents for medical imaging. Adv Drug Deliv Rev. 2009; 62(3):329-38. PMC: 2827667. DOI: 10.1016/j.addr.2009.11.005. View

Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G . Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature. 2005; 436(7048):266-71. DOI: 10.1038/nature03889. View

Couillard-Despres S, Finkl R, Winner B, Ploetz S, Wiedermann D, Aigner R . In vivo optical imaging of neurogenesis: watching new neurons in the intact brain. Mol Imaging. 2008; 7(1):28-34. View

Gupta A, Gupta M . Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005; 26(18):3995-4021. DOI: 10.1016/j.biomaterials.2004.10.012. View

Himmelreich U, Weber R, Ramos-Cabrer P, Wegener S, Kandal K, Shapiro E . Improved stem cell MR detectability in animal models by modification of the inhalation gas. Mol Imaging. 2005; 4(2):104-9. DOI: 10.1162/15353500200504196. View

Darsalia V, Kallur T, Kokaia Z . Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum. Eur J Neurosci. 2007; 26(3):605-14. DOI: 10.1111/j.1460-9568.2007.05702.x. View

10.

van Velthoven C, Kavelaars A, van Bel F, Heijnen C . Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes. Brain Res Rev. 2009; 61(1):1-13. DOI: 10.1016/j.brainresrev.2009.03.003. View

11.

Tung C . Fluorescent peptide probes for in vivo diagnostic imaging. Biopolymers. 2004; 76(5):391-403. DOI: 10.1002/bip.20139. View

12.

Karussis D, Kassis I, Kurkalli B, Slavin S . Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): a proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases. J Neurol Sci. 2007; 265(1-2):131-5. DOI: 10.1016/j.jns.2007.05.005. View

13.

Veizovic T, Beech J, Stroemer R, Watson W, Hodges H . Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells. Stroke. 2001; 32(4):1012-9. DOI: 10.1161/01.str.32.4.1012. View

14.

Farr T, Seehafer J, Nelles M, Hoehn M . Challenges towards MR imaging of the peripheral inflammatory response in the subacute and chronic stages of transient focal ischemia. NMR Biomed. 2010; 24(1):35-45. DOI: 10.1002/nbm.1553. View

15.

Kim D, Schellingerhout D, Ishii K, Shah K, Weissleder R . Imaging of stem cell recruitment to ischemic infarcts in a murine model. Stroke. 2004; 35(4):952-7. DOI: 10.1161/01.STR.0000120308.21946.5D. View

16.

Elhami E, Goertzen A, Xiang B, Deng J, Stillwell C, Mzengeza S . Viability and proliferation potential of adipose-derived stem cells following labeling with a positron-emitting radiotracer. Eur J Nucl Med Mol Imaging. 2011; 38(7):1323-34. DOI: 10.1007/s00259-011-1753-9. View

17.

Strijkers G, Mulder W, van Heeswijk R, Frederik P, Bomans P, Magusin P . Relaxivity of liposomal paramagnetic MRI contrast agents. MAGMA. 2005; 18(4):186-92. DOI: 10.1007/s10334-005-0111-y. View

18.

Shapiro E, Skrtic S, Sharer K, Hill J, Dunbar C, Koretsky A . MRI detection of single particles for cellular imaging. Proc Natl Acad Sci U S A. 2004; 101(30):10901-6. PMC: 503717. DOI: 10.1073/pnas.0403918101. View

19.

Couillard-Despres S, Vreys R, Aigner L, Van Der Linden A . In vivo monitoring of adult neurogenesis in health and disease. Front Neurosci. 2011; 5:67. PMC: 3093743. DOI: 10.3389/fnins.2011.00067. View

20.

Mulder W, Strijkers G, Griffioen A, van Bloois L, Molema G, Storm G . A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets. Bioconjug Chem. 2004; 15(4):799-806. DOI: 10.1021/bc049949r. View