A Simple Method for the Electrophilic Cyanation of Secondary Amines

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2013 Dec 10

PMID 24313859

Citations 4

Authors

Chen Zhu

Ji-Bao Xia

Chuo Chen

Affiliations

Soon will be listed here.

Abstract

Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with an amine nucleophile. This oxidative N-cyanation reaction allows for the preparation of disubstituted cyanamides from amines without using highly toxic cyanogen halides.

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