Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals

Overview

Journal Inorg Chem

Specialty Chemistry

Date 2013 Dec 10

PMID 24313747

Citations 33

Authors

Brian M Zeglis

Jacob L Houghton

Michael J Evans

Nerissa Viola-Villegas

Jason S Lewis

Affiliations

Soon will be listed here.

Abstract

Over the past several decades, radionuclides have matured from largely esoteric and experimental technologies to indispensible components of medical diagnostics. Driving this transition, in part, have been mutually necessary advances in biomedical engineering, nuclear medicine, and cancer biology. Somewhat unsung has been the seminal role of inorganic chemistry in fostering the development of new radiotracers. In this regard, the purpose of this Forum Article is to more visibly highlight the significant contributions of inorganic chemistry to nuclear imaging by detailing the development of five metal-based imaging agents: (64)Cu-ATSM, (68)Ga-DOTATOC, (89)Zr-transferrin, (99m)Tc-sestamibi, and (99m)Tc-colloids. In a concluding section, several unmet needs both in and out of the laboratory will be discussed to stimulate conversation between inorganic chemists and the imaging community.

Citing Articles

Equilibrium Thermodynamics of Macropa Complexes with Selected Metal Isotopes of Radiopharmaceutical Interest.

Blei M, Waurick L, Reissig F, Kopka K, Stumpf T, Drobot B Inorg Chem. 2023; 62(50):20699-20709.

PMID: 37702665 PMC: 10731647. DOI: 10.1021/acs.inorgchem.3c01983.

Scandium-44: Diagnostic Feasibility in Tumor-Related Angiogenesis.

Trencsenyi G, Kepes Z Int J Mol Sci. 2023; 24(8).

PMID: 37108559 PMC: 10138813. DOI: 10.3390/ijms24087400.

Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals.

Phipps M, Cingoranelli S, Bhupathiraju N, Younes A, Cao M, Sanders V Inorg Chem. 2023; 62(50):20567-20581.

PMID: 36724083 PMC: 10390652. DOI: 10.1021/acs.inorgchem.2c03931.

Antibody-Based In Vivo Imaging of Central Nervous System Targets-Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines.

Bredack C, Edelmann M, Borroni E, Gobbi L, Honer M Pharmaceuticals (Basel). 2022; 15(12).

PMID: 36558900 PMC: 9787164. DOI: 10.3390/ph15121445.

The synthesis of a Tc-labeled tetravalent targeting probe upon isonitrile coordination to Tc for enhanced target uptake in saturable systems.

Mizuno Y, Uehara T, Jen C, Akizawa H, Arano Y RSC Adv. 2022; 9(45):26126-26135.

PMID: 35531015 PMC: 9070385. DOI: 10.1039/c9ra04311j.

References

Simecek J, Schulz M, Notni J, Plutnar J, Kubicek V, Havlickova J . Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium. Inorg Chem. 2012; 51(1):577-90. DOI: 10.1021/ic202103v. View

Anderson C, Welch M . Radiometal-labeled agents (non-technetium) for diagnostic imaging. Chem Rev. 2001; 99(9):2219-34. DOI: 10.1021/cr980451q. View

Holland J, Barnard P, Collison D, Dilworth J, Edge R, Green J . Spectroelectrochemical and computational studies on the mechanism of hypoxia selectivity of copper radiopharmaceuticals. Chemistry. 2008; 14(19):5890-907. DOI: 10.1002/chem.200800539. View

Chanson P, Timsit J, Harris A . Clinical pharmacokinetics of octreotide. Therapeutic applications in patients with pituitary tumours. Clin Pharmacokinet. 1993; 25(5):375-91. DOI: 10.2165/00003088-199325050-00004. View

Yuan H, Schroeder T, Bowsher J, Hedlund L, Wong T, Dewhirst M . Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med. 2006; 47(6):989-98. View

Maecke H, Riesen A, Ritter W . The molecular structure of indium-DTPA. J Nucl Med. 1989; 30(7):1235-9. View

Dehdashti F, Mintun M, Lewis J, Bradley J, Govindan R, Laforest R . In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM. Eur J Nucl Med Mol Imaging. 2003; 30(6):844-50. DOI: 10.1007/s00259-003-1130-4. View

Jurisson S, Cutler C, Smith S . Radiometal complexes: characterization and relevant in vitro studies. Q J Nucl Med Mol Imaging. 2008; 52(3):222-34. View

Dehdashti F, Grigsby P, Lewis J, Laforest R, Siegel B, Welch M . Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone). J Nucl Med. 2008; 49(2):201-5. DOI: 10.2967/jnumed.107.048520. View

10.

Takahashi N, Fujibayashi Y, Yonekura Y, Welch M, Waki A, Tsuchida T . Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia. Ann Nucl Med. 2001; 15(3):293-6. DOI: 10.1007/BF02987849. View

11.

DOBSON E, GOFMAN J . Studies with colloids containing radioisotopes of yttrium, zirconium, columbium, and lanthanum; the controlled selective localization of radioisotopes of yttrium, zirconium, and columbium in the bone marrow, liver, and spleen. J Lab Clin Med. 1949; 34(3):305-12. View

12.

Vavere A, Welch M . Preparation, biodistribution, and small animal PET of 45Ti-transferrin. J Nucl Med. 2005; 46(4):683-90. View

13.

Zhernosekov K, Filosofov D, Baum R, Aschoff P, Bihl H, Razbash A . Processing of generator-produced 68Ga for medical application. J Nucl Med. 2007; 48(10):1741-8. DOI: 10.2967/jnumed.107.040378. View

14.

Palmedo H, Biersack H, Lastoria S, Maublant J, Prats E, Stegner H . Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial. Eur J Nucl Med. 1998; 25(4):375-85. DOI: 10.1007/s002590050235. View

15.

Arrago J, Rain J, Vigneron N, Poirier O, Chomienne C, DAgay M . Diagnostic value of bone marrow imaging with 111indium-transferrin and 99m technetium-colloids in myelofibrosis. Am J Hematol. 1985; 18(3):275-82. DOI: 10.1002/ajh.2830180309. View

16.

Kelkar S, Reineke T . Theranostics: combining imaging and therapy. Bioconjug Chem. 2011; 22(10):1879-903. DOI: 10.1021/bc200151q. View

17.

ODonnell K, Yu D, Zeller K, Kim J, Racke F, Thomas-Tikhonenko A . Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis. Mol Cell Biol. 2006; 26(6):2373-86. PMC: 1430295. DOI: 10.1128/MCB.26.6.2373-2386.2006. View

18.

Prost A, Anakok M, Aurengo A, SALOMON J, Legrand J, Rosselin G . Tissue distribution of 131I radiolabeled transferrin in the athymic nude mouse: localization of a human colon adenocarcinoma HT-29 xenograft. Int J Rad Appl Instrum B. 1990; 17(2):209-16. DOI: 10.1016/0883-2897(90)90149-u. View

19.

Wood K, Wong W, Saunders M . [(64)Cu]diacetyl-bis(N(4)-methyl-thiosemicarbazone) - a radiotracer for tumor hypoxia. Nucl Med Biol. 2008; 35(4):393-400. DOI: 10.1016/j.nucmedbio.2008.02.002. View

20.

Wadas T, Anderson C . Radiolabeling of TETA- and CB-TE2A-conjugated peptides with copper-64. Nat Protoc. 2007; 1(6):3062-8. DOI: 10.1038/nprot.2006.431. View