NOD-Like Receptors in Lung Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2013 Dec 7

PMID 24312100

Citations 38

Authors

Catherine Chaput

Leif Erik Sander

Norbert Suttorp

Bastian Opitz

Affiliations

Soon will be listed here.

Abstract

The lung is a particularly vulnerable organ at the interface of the body and the exterior environment. It is constantly exposed to microbes and particles by inhalation. The innate immune system needs to react promptly and adequately to potential dangers posed by these microbes and particles, while at the same time avoiding extensive tissue damage. Nucleotide-binding oligomerization domain-like receptors (NLRs) represent a group of key sensors for microbes and damage in the lung. As such they are important players in various infectious as well as acute and chronic sterile inflammatory diseases, such as pneumonia, chronic obstructive pulmonary disease (COPD), acute lung injury/acute respiratory distress syndrome, pneumoconiosis, and asthma. Activation of most known NLRs leads to the production and release of pro-inflammatory cytokines, and/or to the induction of cell death. We will review NLR functions in the lung during infection and sterile inflammation.

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