Possible Biases in Heritability Estimates from Intraclass Correlation
Overview
Authors
Affiliations
There is an inherent bias in intraclass correlations since the expectation of a ratio does not equal the ratio of expectations. A simple accurate approximation for this bias is derived, and it is found that the inherent bias is usually negligible. Selection of sires is known to bias half-sib heritability estimates, and appropriate formulae are given and discussed.
Woo M, Heo M, Devane A, Lowe S, Gimbel R BMJ Open. 2020; 10(11):e040096.
PMID: 33191265 PMC: 7668356. DOI: 10.1136/bmjopen-2020-040096.
estimation of genetic variation of functional and ecological traits in and .
Alexandre H, Truffaut L, Ducousso A, Louvet J, Nepveu G, Torres-Ruiz J Tree Genet Genomes. 2020; 16.
PMID: 32256274 PMC: 7136077. DOI: 10.1007/s11295-019-1407-9.
Bobak C, Barr P, OMalley A BMC Med Res Methodol. 2018; 18(1):93.
PMID: 30208858 PMC: 6134634. DOI: 10.1186/s12874-018-0550-6.
Gomez-Raya L, Schaeffer L, Burnside E Theor Appl Genet. 2013; 81(5):624-8.
PMID: 24221377 DOI: 10.1007/BF00226728.
Bias of maximum likelihood estimator of intraclass correlation.
Wang C, Yandell B, Rutledge J Theor Appl Genet. 2013; 82(4):421-4.
PMID: 24213257 DOI: 10.1007/BF00588594.