The Association of APE1 Asp148Glu Gene Polymorphisms and Lung Cancer Risk: an Updated Meta-analysis

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Dec 7

PMID 24310503

Citations 2

Authors

Wen Chen

Qin Wang

Mang Liu

Xiao-bing Ding

Affiliations

Soon will be listed here.

Abstract

Many studies have examined the association between APE1 Asp148Glu (rs3136820) polymorphism gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. PubMed and CNKI databases were searched for case-control studies published up to October 2013. Data were extracted, and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Ultimately, 14 studies, comprising 4,165 lung cancer cases and 5,438 controls were included. Overall, for Glu carriers (Asp/Glu + Glu/Glu) versus wild-type homozygotes (Asp/Asp), the pooled OR was 1.05 (95% CI = 0.96-1.15 P = 0.000 for heterogeneity); for Glu/Glu versus Asp/Asp, the pooled OR was 1.07 (95% CI = 0.95-1.21 P = 0.007 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were not found among Asians or Caucasians. This updated meta-analysis suggests that the APE1 Asp148Glu polymorphisms are not associated with lung cancer risk among Asians or Caucasians.

Citing Articles

Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk.

Sevilya Z, Leitner-Dagan Y, Pinchev M, Kremer R, Elinger D, Lejbkowicz F Carcinogenesis. 2015; 36(9):982-91.

PMID: 26045303 PMC: 4552243. DOI: 10.1093/carcin/bgv082.

Evaluating the association of polymorphisms in the HAP1 gene with lung cancer risk: a meta-analysis.

Wang W, Yan H, Zhang Q, Song W, Li H, Xu J Tumour Biol. 2014; 35(11):10825-31.

PMID: 25081373 DOI: 10.1007/s13277-014-2236-y.

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