What We Know Currently About Mirror Neurons

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2013 Dec 7

PMID 24309286

Citations 91

Authors

J M Kilner

R N Lemon

Affiliations

Soon will be listed here.

Abstract

Mirror neurons were discovered over twenty years ago in the ventral premotor region F5 of the macaque monkey. Since their discovery much has been written about these neurons, both in the scientific literature and in the popular press. They have been proposed to be the neuronal substrate underlying a vast array of different functions. Indeed so much has been written about mirror neurons that last year they were referred to, rightly or wrongly, as "The most hyped concept in neuroscience". Here we try to cut through some of this hyperbole and review what is currently known (and not known) about mirror neurons.

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References

Ferrari P, Rozzi S, Fogassi L . Mirror neurons responding to observation of actions made with tools in monkey ventral premotor cortex. J Cogn Neurosci. 2005; 17(2):212-26. DOI: 10.1162/0898929053124910. View

Rochat M, Caruana F, Jezzini A, Escola L, Intskirveli I, Grammont F . Responses of mirror neurons in area F5 to hand and tool grasping observation. Exp Brain Res. 2010; 204(4):605-16. PMC: 2903687. DOI: 10.1007/s00221-010-2329-9. View

Tkach D, Reimer J, Hatsopoulos N . Congruent activity during action and action observation in motor cortex. J Neurosci. 2007; 27(48):13241-50. PMC: 6673404. DOI: 10.1523/JNEUROSCI.2895-07.2007. View

Rozzi S, Ferrari P, Bonini L, Rizzolatti G, Fogassi L . Functional organization of inferior parietal lobule convexity in the macaque monkey: electrophysiological characterization of motor, sensory and mirror responses and their correlation with cytoarchitectonic areas. Eur J Neurosci. 2008; 28(8):1569-88. DOI: 10.1111/j.1460-9568.2008.06395.x. View

Kraskov A, Dancause N, Quallo M, Shepherd S, Lemon R . Corticospinal neurons in macaque ventral premotor cortex with mirror properties: a potential mechanism for action suppression?. Neuron. 2010; 64(6):922-30. PMC: 2862290. DOI: 10.1016/j.neuron.2009.12.010. View

Peeters R, Simone L, Nelissen K, Fabbri-Destro M, Vanduffel W, Rizzolatti G . The representation of tool use in humans and monkeys: common and uniquely human features. J Neurosci. 2009; 29(37):11523-39. PMC: 6665774. DOI: 10.1523/JNEUROSCI.2040-09.2009. View

Mukamel R, Ekstrom A, Kaplan J, Iacoboni M, Fried I . Single-neuron responses in humans during execution and observation of actions. Curr Biol. 2010; 20(8):750-6. PMC: 2904852. DOI: 10.1016/j.cub.2010.02.045. View

Nelissen K, Luppino G, Vanduffel W, Rizzolatti G, Orban G . Observing others: multiple action representation in the frontal lobe. Science. 2005; 310(5746):332-6. DOI: 10.1126/science.1115593. View

Yamazaki Y, Yokochi H, Tanaka M, Okanoya K, Iriki A . Potential role of monkey inferior parietal neurons coding action semantic equivalences as precursors of parts of speech. Soc Neurosci. 2010; 5(1):105-17. PMC: 2826156. DOI: 10.1080/17470910802625306. View

10.

Kilner J, Friston K, Frith C . Predictive coding: an account of the mirror neuron system. Cogn Process. 2007; 8(3):159-66. PMC: 2649419. DOI: 10.1007/s10339-007-0170-2. View

11.

Grill-Spector K, Henson R, Martin A . Repetition and the brain: neural models of stimulus-specific effects. Trends Cogn Sci. 2005; 10(1):14-23. DOI: 10.1016/j.tics.2005.11.006. View

12.

Fogassi L, Ferrari P, Gesierich B, Rozzi S, Chersi F, Rizzolatti G . Parietal lobe: from action organization to intention understanding. Science. 2005; 308(5722):662-7. DOI: 10.1126/science.1106138. View

13.

Gallese V, Fadiga L, Fogassi L, Rizzolatti G . Action recognition in the premotor cortex. Brain. 1996; 119 ( Pt 2):593-609. DOI: 10.1093/brain/119.2.593. View

14.

Press C, Weiskopf N, Kilner J . Dissociable roles of human inferior frontal gyrus during action execution and observation. Neuroimage. 2012; 60(3):1671-7. PMC: 3399774. DOI: 10.1016/j.neuroimage.2012.01.118. View

15.

di Pellegrino G, Fadiga L, Fogassi L, Gallese V, Rizzolatti G . Understanding motor events: a neurophysiological study. Exp Brain Res. 1992; 91(1):176-80. DOI: 10.1007/BF00230027. View

16.

Fujii N, Hihara S, Iriki A . Dynamic social adaptation of motion-related neurons in primate parietal cortex. PLoS One. 2007; 2(4):e397. PMC: 1851098. DOI: 10.1371/journal.pone.0000397. View

17.

Shepherd S, Klein J, Deaner R, Platt M . Mirroring of attention by neurons in macaque parietal cortex. Proc Natl Acad Sci U S A. 2009; 106(23):9489-94. PMC: 2685741. DOI: 10.1073/pnas.0900419106. View

18.

Molenberghs P, Cunnington R, Mattingley J . Brain regions with mirror properties: a meta-analysis of 125 human fMRI studies. Neurosci Biobehav Rev. 2011; 36(1):341-9. DOI: 10.1016/j.neubiorev.2011.07.004. View

19.

Caggiano V, Fogassi L, Rizzolatti G, Pomper J, Thier P, Giese M . View-based encoding of actions in mirror neurons of area f5 in macaque premotor cortex. Curr Biol. 2011; 21(2):144-8. DOI: 10.1016/j.cub.2010.12.022. View

20.

Dushanova J, Donoghue J . Neurons in primary motor cortex engaged during action observation. Eur J Neurosci. 2010; 31(2):386-98. PMC: 2862560. DOI: 10.1111/j.1460-9568.2009.07067.x. View