Remote Ischemic Preconditioning and Renoprotection: from Myth to a Novel Therapeutic Option?

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2013 Dec 7

PMID 24309187

Citations 62

Authors

Natig Gassanov

Amir M Nia

Evren Caglayan

Fikret Er

Affiliations

Soon will be listed here.

Abstract

There is currently no effective prophylactic regimen available to prevent contrast-induced AKI (CI-AKI), a frequent and life-threatening complication after cardiac catheterization. Therefore, novel treatment strategies are required to decrease CI-AKI incidence and to improve clinical outcomes in these patients. Remote ischemic preconditioning (rIPC), defined as transient brief episodes of ischemia at a remote site before a subsequent prolonged ischemia/reperfusion injury of the target organ, is an adaptational response that protects against ischemic and reperfusion insult. Indeed, several studies demonstrated the tissue-protective effects of rIPC in various target organs, including the kidneys. In this regard, rIPC may offer a novel noninvasive and virtually cost-free treatment strategy for decreasing CI-AKI incidence. This review evaluates the current experimental and clinical evidence for rIPC as a potential renoprotective strategy, and discusses the underlying mechanisms and key areas for future research.

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