Biochemical Analysis of the Articular Disc of the Temporomandibular Joint with Magnetic Resonance T2 Mapping: a Feasibility Study

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2013 Dec 6

PMID 24306680

Citations 10

Authors

Martina Schmid-Schwap

Margit Bristela

Elisabeth Pittschieler

Astrid Skolka

Pavol Szomolanyi

Michael Weber

Eva Piehslinger

Siegfried Trattnig

Affiliations

Soon will be listed here.

Abstract

Objectives: Symptoms of temporomandibular joint (TMJ) dysfunction can seriously compromise patients' quality of life. The aim of our study was to use magnetic resonance imaging (MRI) T2 mapping of the articular disc to determine whether T2 mapping of the TMJ disc is feasible in routine clinical imaging and to assess the normal T2 relaxation time distribution within the TMJ.

Methods: Included were ten asymptomatic volunteers without pain, any mouth-opening limitations, or any clicking phenomena. MR imaging was performed on a 3-T MR scanner using a flexible, dedicated, eight-channel multielement coil. T2 mapping was performed in the oblique sagittal plane. The regions of interest (ROIs) for the T2 relaxation time maps of the disc were selected manually.

Results: The mean values for ROIs ranged between 22.4 and 28.8 ms, and the mean for all ROIs was 26.0 ± 5.0 ms. Intraclass correlation (ICC) for interobserver variability was 0.698, and ICC for intraobserver variability was 0.861. There was no statistically significant difference between raters (p = 0.091) or sides (p = 0.810).

Conclusion: The T2 mapping technique enables ultrastructural analysis of the composition of TMJ disc. This biochemical technique is feasible in vivo, as shown in our study, when a high-field (3 T) MR and a dedicated TMJ coil are used.

Clinical Relevance: T2 mapping as a biochemical technique, together with morphological MRI, may help to gain more insights into the physiology and into the pathophysiology of the articular disc in the TMJ noninvasively and in vivo.

Citing Articles

Evaluation of the Articular Disc Using the Magnetic Resonance Cartigram in Asymptomatic and Symptomatic Temporomandibular Disorders.

Sivakumar A, Ganesan A, Lakshmi K, Aniyan Y, Kannan S Indian J Radiol Imaging. 2024; 35(1):50-58.

PMID: 39697496 PMC: 11651835. DOI: 10.1055/s-0044-1788608.

Comparison of T2 values of the displaced unilateral disc and retrodiscal tissue of temporomandibular joints and their implications.

Kakimoto N, Wongratwanich P, Shimamoto H, Kitisubkanchana J, Tsujimoto T, Shimabukuro K Sci Rep. 2024; 14(1):1705.

PMID: 38242921 PMC: 10798969. DOI: 10.1038/s41598-024-52092-6.

Intra- and inter-examination reproducibility of T2 mapping for temporomandibular joint assessment at 3.0 T.

Wongratwanich P, Nagasaki T, Shimabukuro K, Konishi M, Ohtsuka M, Suei Y Sci Rep. 2022; 12(1):10993.

PMID: 35768628 PMC: 9243045. DOI: 10.1038/s41598-022-15184-9.

Temporomandibular Disk Dislocation Impacts the Stomatognathic System: Comparative Study Based on Biexponential Quantitative T2 Maps.

Regulski P, Zielinski J, Szopinski K J Clin Med. 2022; 11(6).

PMID: 35329946 PMC: 8953096. DOI: 10.3390/jcm11061621.

Comparison of T2 Weighted, Fat-Suppressed T2 Weighted, and Three-Dimensional (3D) Fast Imaging Employing Steady-State Acquisition (FIESTA-C) Sequences in the Temporomandibular Joint (TMJ) Evaluation.

Aksoy S, Orhan K Biomed Res Int. 2022; 2021:6032559.

PMID: 34977244 PMC: 8716192. DOI: 10.1155/2021/6032559.

References

Matzat S, van Tiel J, Gold G, Oei E . Quantitative MRI techniques of cartilage composition. Quant Imaging Med Surg. 2013; 3(3):162-74. PMC: 3701096. DOI: 10.3978/j.issn.2223-4292.2013.06.04. View

Rudisch A, Innerhofer K, Bertram S, Emshoff R . Magnetic resonance imaging findings of internal derangement and effusion in patients with unilateral temporomandibular joint pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92(5):566-71. DOI: 10.1067/moe.2001.116817. View

Segami N, Suzuki T, Sato J, Miyamaru M, Nishimura M, Yoshimura H . Does joint effusion on T2 magnetic resonance images reflect synovitis? Part 3. Comparison of histologic findings of arthroscopically obtained synovium in internal derangements of the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95(6):761-6. DOI: 10.1067/moe.2003.243. View

Limchaichana N, Nilsson H, Ekberg E, Nilner M, Petersson A . Clinical diagnoses and MRI findings in patients with TMD pain. J Oral Rehabil. 2007; 34(4):237-45. DOI: 10.1111/j.1365-2842.2006.01719.x. View

Emshoff R, Rudisch A . Validity of clinical diagnostic criteria for temporomandibular disorders: clinical versus magnetic resonance imaging diagnosis of temporomandibular joint internal derangement and osteoarthrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 91(1):50-5. DOI: 10.1067/moe.2001.111129. View

Van Breuseghem I, Bosmans H, Vander Elst L, Maes F, Pans S, Brys P . T2 mapping of human femorotibial cartilage with turbo mixed MR imaging at 1.5 T: feasibility. Radiology. 2004; 233(2):609-14. DOI: 10.1148/radiol.2332030891. View

Roh H, Kim W, Kim Y, Lee J . Relationships between disk displacement, joint effusion, and degenerative changes of the TMJ in TMD patients based on MRI findings. J Craniomaxillofac Surg. 2011; 40(3):283-6. DOI: 10.1016/j.jcms.2011.04.006. View

Dahlstrom L, Carlsson G . Temporomandibular disorders and oral health-related quality of life. A systematic review. Acta Odontol Scand. 2010; 68(2):80-5. DOI: 10.3109/00016350903431118. View

Schmid-Schwap M, Briedl J, Robinson S, Piehslinger E . Correlation between disk morphology on MRI and time curves using electronic axiography. Cranio. 2005; 23(1):22-9. DOI: 10.1179/crn.2005.005. View

10.

Stelzeneder D, Messner A, Vlychou M, Welsch G, Scheurecker G, Goed S . Quantitative in vivo MRI evaluation of lumbar facet joints and intervertebral discs using axial T2 mapping. Eur Radiol. 2011; 21(11):2388-95. DOI: 10.1007/s00330-011-2198-z. View

11.

Maizlin Z, Clement J, Patola W, Fenton D, Gillies J, Vos P . T2 mapping of articular cartilage of glenohumeral joint with routine MRI correlation--initial experience. HSS J. 2009; 5(1):61-6. PMC: 2642550. DOI: 10.1007/s11420-008-9106-3. View

12.

Katzberg R, Tallents R . Normal and abnormal temporomandibular joint disc and posterior attachment as depicted by magnetic resonance imaging in symptomatic and asymptomatic subjects. J Oral Maxillofac Surg. 2005; 63(8):1155-61. DOI: 10.1016/j.joms.2005.04.012. View

13.

Sano T, Westesson P . Magnetic resonance imaging of the temporomandibular joint. Increased T2 signal in the retrodiskal tissue of painful joints. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 79(4):511-6. DOI: 10.1016/s1079-2104(05)80138-6. View

14.

Marik W, Apprich S, Welsch G, Mamisch T, Trattnig S . Biochemical evaluation of articular cartilage in patients with osteochondrosis dissecans by means of quantitative T2- and T2-mapping at 3T MRI: a feasibility study. Eur J Radiol. 2011; 81(5):923-7. DOI: 10.1016/j.ejrad.2011.01.124. View

15.

Quaia E, Toffanin R, Guglielmi G, Ukmar M, Rossi A, Martinelli B . Fast T2 mapping of the patellar articular cartilage with gradient and spin-echo magnetic resonance imaging at 1.5 T: validation and initial clinical experience in patients with osteoarthritis. Skeletal Radiol. 2008; 37(6):511-7. DOI: 10.1007/s00256-008-0478-8. View

16.

Stehling C, Vieth V, Bachmann R, Nassenstein I, Kugel H, Kooijman H . High-resolution magnetic resonance imaging of the temporomandibular joint: image quality at 1.5 and 3.0 Tesla in volunteers. Invest Radiol. 2007; 42(6):428-34. DOI: 10.1097/01.rli.0000262081.23997.6b. View

17.

Battaglia M, Vannini F, Buda R, Cavallo M, Ruffilli A, Monti C . Arthroscopic autologous chondrocyte implantation in osteochondral lesions of the talus: mid-term T2-mapping MRI evaluation. Knee Surg Sports Traumatol Arthrosc. 2011; 19(8):1376-84. DOI: 10.1007/s00167-011-1509-x. View

18.

Segami N, Nishimura M, Kaneyama K, Miyamaru M, Sato J, Murakami K . Does joint effusion on T2 magnetic resonance images reflect synovitis? Comparison of arthroscopic findings in internal derangements of the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92(3):341-5. DOI: 10.1067/moe.2001.117808. View

19.

Welsch G, Mamisch T, Quirbach S, Zak L, Marlovits S, Trattnig S . Evaluation and comparison of cartilage repair tissue of the patella and medial femoral condyle by using morphological MRI and biochemical zonal T2 mapping. Eur Radiol. 2008; 19(5):1253-62. DOI: 10.1007/s00330-008-1249-6. View

20.

Mosher T, Dardzinski B . Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol. 2005; 8(4):355-68. DOI: 10.1055/s-2004-861764. View