Osteocalcin Increase After Bariatric Surgery Predicts Androgen Recovery in Hypogonadal Obese Males

Overview

Journal Int J Obes (Lond)

Specialty Endocrinology

Date 2013 Dec 6

PMID 24304595

Citations 9

Authors

J Samavat

E Facchiano

G Cantini

A Di Franco

G Alpigiano

G Poli

G Seghieri

M Lucchese

G Forti

M Luconi

Affiliations

Soon will be listed here.

Abstract

Objective: Bone modulates testis function through osteocalcin (OCN) production. This paper assesses the association between serum OCN and androgen production recovery in morbidly obese males at 9 months after bariatric surgery.

Subjects: A cohort of n=103 obese males with mean±s.d. body mass index (BMI) 47.7±8.2 kg m(-2), age 42±11 years, consisting of n=76 patients undergoing gastric bypass and n=27 in the waiting list for surgery.

Results: At 9 months from surgery, a significant increase was observed in mean±s.d. total OCN (tOCN=10.4±10.3 ng ml(-1), P<0.001) and undercarboxylated OCN (ucOCN=5.4±3.7 ng ml(-1), P<0.001), total testosterone (TT, 5.6±6.5 nM, P<0.001) and calculated free testosterone (cFT, 0.035±0.133 nM, P<0.006), sex hormone binding globulin (SHBG, 21.2±16.7 nM, P<0.001) and decrease in estradiol (E2, -30.1±51.9 pM, P<0.001) levels only in operated patients, with a significant reduction in BMI (24%) and waist (20%). A positive correlation existed between tOCN and ucOCN (age-adjustment (age-adj.): β=0.692, P<0.001) and their variations (age-adj.: β=0.629, P<0.001) after surgery. Multivariate analysis in operated patients showed a significant positive association between variations in tOCN and TT (age-adj.: β=0.289, P=0.012), SHBG (age-adj.: β=0.326, P=0.005) but not with cFT variation. tOCN, but not luteinizing hormone (LH) variation was the only significant predictive factor of cFT recovery in the hypogonadal (TT<12 nM) operated subjects even after age- and BMI-adjustment (adj.: β=0.582, P<0.05). cFT improvement was significantly higher when considering operated patients with tOCN increase (0.045±0.123 vs -0.02±0.118 nM, P=0.015), hypogonadism (0.059±0.111 vs -0.059±0.138 nM, P=0.002) and younger than 35 years (0.102±0.108 vs -0.019±0.123 nM, P=0.009).

Conclusion: OCN recovery observed after bariatric surgery is significantly associated with cFT improvement independently of BMI variation and age in hypogonadal morbidly obese males.

Citing Articles

Total osteocalcin levels are independently associated with worse testicular function and a higher degree of hypothalamic-pituitary-gonadal axis activation in Klinefelter syndrome.

Carlomagno F, Hasenmajer V, Spaziani M, Tenuta M, Sesti F, Tarantino C J Endocrinol Invest. 2024; 47(12):3049-3056.

PMID: 38773059 PMC: 11549210. DOI: 10.1007/s40618-024-02390-7.

Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery.

Sultan S, Patel A, El-Hassani S, Whitelaw B, Leca B, Vincent R Front Endocrinol (Lausanne). 2020; 11:408.

PMID: 32636807 PMC: 7318874. DOI: 10.3389/fendo.2020.00408.

Osteocalcin Levels in Male Idiopathic Hypogonadotropic Hypogonadism: Relationship With the Testosterone Secretion and Metabolic Profiles.

Yang Y, Zheng S, Wang W, Yang Z, Shan C, Zhang Y Front Endocrinol (Lausanne). 2019; 10:687.

PMID: 31681165 PMC: 6798147. DOI: 10.3389/fendo.2019.00687.

Metabolic and Endocrine Consequences of Bariatric Surgery.

Cornejo-Pareja I, Clemente-Postigo M, Tinahones F Front Endocrinol (Lausanne). 2019; 10:626.

PMID: 31608009 PMC: 6761298. DOI: 10.3389/fendo.2019.00626.

Obesity, Male Reproductive Function and Bariatric Surgery.

Di Vincenzo A, Busetto L, Vettor R, Rossato M Front Endocrinol (Lausanne). 2019; 9:769.

PMID: 30619096 PMC: 6305362. DOI: 10.3389/fendo.2018.00769.

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