Chromosomal Bands Affected by Acute Oil Exposure and DNA Repair Errors

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Dec 5

PMID 24303039

Citations 3

Authors

Gemma Monyarch

Fernanda de Castro Reis

Jan-Paul Zock

Jesus Giraldo

Francisco Pozo-Rodriguez

Ana Espinosa

Gema Rodriguez-Trigo

Hector Verea

Gemma Castano-Vinyals

Federico P Gomez

Josep M Anto

Maria Dolors Coll

Joan Albert Barbera

Carme Fuster

Affiliations

Soon will be listed here.

Abstract

Background: In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk.

Objectives: We analyzed whether the breakpoints involved in chromosomal damage can help to assess the risk of cancer as well as to investigate their possible association with DNA repair efficiency.

Methods: Cytogenetic analyses were carried out on the same individuals of our previous study and DNA repair errors were assessed in cultures with aphidicolin.

Results: Three chromosomal bands, 2q21, 3q27 and 5q31, were most affected by acute oil exposure. The dysfunction in DNA repair mechanisms, expressed as chromosomal damage, was significantly higher in exposed-oil participants than in those not exposed (p= 0.016).

Conclusion: The present study shows that breaks in 2q21, 3q27 and 5q31 chromosomal bands, which are commonly involved in hematological cancer, could be considered useful genotoxic oil biomarkers. Moreover, breakages in these bands could induce chromosomal instability, which can explain the increased risk of cancer (leukemia and lymphomas) reported in chronically benzene-exposed individuals. In addition, it has been determined that the individuals who participated in clean-up of the oil spill presented an alteration of their DNA repair mechanisms two years after exposure.

Citing Articles

Association between occupational exposure to gasoline and anemia: a retrospective cohort study in China.

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Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas.

Cordiano R, Papa V, Cicero N, Spatari G, Allegra A, Gangemi S Toxics. 2022; 10(11).

PMID: 36355969 PMC: 9697938. DOI: 10.3390/toxics10110678.

Persistence of Breakage in Specific Chromosome Bands 6 Years after Acute Exposure to Oil.

Frances A, Hildur K, Barbera J, Rodriguez-Trigo G, Zock J, Giraldo J PLoS One. 2016; 11(8):e0159404.

PMID: 27479010 PMC: 4969035. DOI: 10.1371/journal.pone.0159404.

Follow-Up Genotoxic Study: Chromosome Damage Two and Six Years after Exposure to the Prestige Oil Spill.

Hildur K, Templado C, Zock J, Giraldo J, Pozo-Rodriguez F, Frances A PLoS One. 2015; 10(7):e0132413.

PMID: 26221948 PMC: 4519162. DOI: 10.1371/journal.pone.0132413.

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