Tgf-Beta Family Signaling in Embryonic Stem Cells

Overview

Journal Int J Stem Cells

Date 2013 Dec 4

PMID 24298330

Citations 19

Authors

Kyung-Soon Park

Affiliations

Soon will be listed here.

Abstract

Ligands of transforming growth factor beta (TGF-β) family members have been implicated in the development and patho-physiological process of various organs. Embryonic stem cells (ESCs) are characterized by their ability to proliferate indefinitely and differentiated into all three germ layer cells, which are termed as pluripotency and self-renewal,respectively. For successful therapeutic application of ESCs, it is essential to understand the mechanisms underlying self-renewal and pluripotency, which involve complex networks among key factors including transcription factors, epigenetic control, microRNAs and signaling pathways. In this review, we discuss recent progress on the function of TGF beta family ligands and their canonical SMAD signaling in the maintenance of ESC' s identity.

Citing Articles

Role of Native Probiotic Lactobacillus Species via TGF-β Signaling Pathway Modulation in CRC.

Sepehr A, Aghamohammad S, Ghanavati R, Talebi M, Pourshafie M, Rohani M Iran Biomed J. 2024; 28(4):168-78.

PMID: 39279541 PMC: 11444483. DOI: 10.61186/ibj.4012.

SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss.

Lei Y, Al Delbany D, Krivec N, Regin M, Couvreu de Deckersberg E, Janssens C Stem Cell Reports. 2024; 19(4):562-578.

PMID: 38552632 PMC: 11096619. DOI: 10.1016/j.stemcr.2024.03.001.

The Role of TGF-β during Pregnancy and Pregnancy Complications.

Wen B, Liao H, Lin W, Li Z, Ma X, Xu Q Int J Mol Sci. 2023; 24(23).

PMID: 38069201 PMC: 10706464. DOI: 10.3390/ijms242316882.

TGF-β and SHH Regulate Pluripotent Stem Cell Differentiation into Brain Microvascular Endothelial Cells in Generating an In Vitro Blood-Brain Barrier Model.

Lee N, Lim M, Park J, Jeung I, Hwang B, Lee J Bioengineering (Basel). 2023; 10(10).

PMID: 37892862 PMC: 10604460. DOI: 10.3390/bioengineering10101132.

Cancer Metabolism: The Role of Immune Cells Epigenetic Alteration in Tumorigenesis, Progression, and Metastasis of Glioma.

Kanwore K, Kanwore K, Adzika G, Abiola A, Guo X, Kambey P Front Immunol. 2022; 13:831636.

PMID: 35392088 PMC: 8980436. DOI: 10.3389/fimmu.2022.831636.

References

Lengerke C, Schmitt S, Bowman T, Jang I, Maouche-Chretien L, McKinney-Freeman S . BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell. 2008; 2(1):72-82. DOI: 10.1016/j.stem.2007.10.022. View

Suzuki Y, Montagne K, Nishihara A, Watabe T, Miyazono K . BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling. J Biochem. 2007; 143(2):199-206. DOI: 10.1093/jb/mvm215. View

Saijoh Y, Adachi H, Sakuma R, Yeo C, Yashiro K, Watanabe M . Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol Cell. 2000; 5(1):35-47. DOI: 10.1016/s1097-2765(00)80401-3. View

Vallier L, Alexander M, Pedersen R . Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci. 2005; 118(Pt 19):4495-509. DOI: 10.1242/jcs.02553. View

Ichida J, Blanchard J, Lam K, Son E, Chung J, Egli D . A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009; 5(5):491-503. PMC: 3335195. DOI: 10.1016/j.stem.2009.09.012. View

Ying Q, Nichols J, Chambers I, Smith A . BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell. 2003; 115(3):281-92. DOI: 10.1016/s0092-8674(03)00847-x. View

Xu R, Sampsell-Barron T, Gu F, Root S, Peck R, Pan G . NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell. 2008; 3(2):196-206. PMC: 2758041. DOI: 10.1016/j.stem.2008.07.001. View

Massague J . Receptors for the TGF-beta family. Cell. 1992; 69(7):1067-70. DOI: 10.1016/0092-8674(92)90627-o. View

Park C, Afrikanova I, Chung Y, Zhang W, Arentson E, Fong Gh G . A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development. 2004; 131(11):2749-62. DOI: 10.1242/dev.01130. View

10.

Dennler S, Goumans M, Ten Dijke P . Transforming growth factor beta signal transduction. J Leukoc Biol. 2002; 71(5):731-40. View

11.

Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K . TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol. 2003; 163(6):1303-11. PMC: 2173713. DOI: 10.1083/jcb.200305147. View

12.

Robertson E, Norris D, Brennan J, Bikoff E . Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci. 2003; 358(1436):1351-7. PMC: 1693235. DOI: 10.1098/rstb.2003.1332. View

13.

Yashiro K, Saijoh Y, Sakuma R, Tada M, Tomita N, Amano K . Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes. Genes Cells. 2000; 5(5):343-57. DOI: 10.1046/j.1365-2443.2000.00329.x. View

14.

James D, Levine A, Besser D, Hemmati-Brivanlou A . TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development. 2005; 132(6):1273-82. DOI: 10.1242/dev.01706. View

15.

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

16.

Adachi H, Saijoh Y, Mochida K, Ohishi S, Hashiguchi H, Hirao A . Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer. Genes Dev. 1999; 13(12):1589-600. PMC: 316797. DOI: 10.1101/gad.13.12.1589. View

17.

Wilson P, Hemmati-Brivanlou A . Induction of epidermis and inhibition of neural fate by Bmp-4. Nature. 1995; 376(6538):331-3. DOI: 10.1038/376331a0. View

18.

Lee D, Park C, Lee H, Lugus J, Hyung Kim S, Arentson E . ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008; 2(5):497-507. PMC: 2683414. DOI: 10.1016/j.stem.2008.03.008. View

19.

Saijoh Y, Adachi H, Mochida K, Ohishi S, Hirao A, Hamada H . Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2. Genes Dev. 1999; 13(3):259-69. PMC: 316429. DOI: 10.1101/gad.13.3.259. View

20.

Klein P, Melton D . A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A. 1996; 93(16):8455-9. PMC: 38692. DOI: 10.1073/pnas.93.16.8455. View