Host Specificity of Bacterial Pathogens

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2013 Dec 4

PMID 24296346

Citations 105

Authors

Andreas Baumler

Ferric C Fang

Affiliations

Soon will be listed here.

Abstract

Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica.

Citing Articles

Preliminary Evidence of Human in Domestic Animals from a Malaria-Endemic Region in Indonesia.

Munirah M, Wahyuni S, Wahid I, Hamid F F1000Res. 2025; 10:645.

PMID: 39931544 PMC: 11809677. DOI: 10.12688/f1000research.53946.3.

pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry.

Tambassi M, Berni M, Bracchi C, Menozzi I, Dodi A, Mazzera L Microbiol Spectr. 2024; 13(1):e0264324.

PMID: 39660884 PMC: 11705904. DOI: 10.1128/spectrum.02643-24.

Genomic insights into a Proteus mirabilis strain inducing avian cellulitis.

de Oliva B, do Nascimento A, de Oliveira J, Guidone G, Schoeps B, Silva L Braz J Microbiol. 2024; 55(4):4157-4166.

PMID: 39235714 PMC: 11711737. DOI: 10.1007/s42770-024-01508-6.

BacSPaD: A Robust Bacterial Strains' Pathogenicity Resource Based on Integrated and Curated Genomic Metadata.

Ribeiro S, Chaumet G, Alves K, Nourikyan J, Shi L, Lavergne J Pathogens. 2024; 13(8).

PMID: 39204272 PMC: 11357117. DOI: 10.3390/pathogens13080672.

Salmonella infections in Denmark from 2013-2022 with focus on serotype distribution, invasiveness, age, sex, and travel exposition.

Aaro N, Torpdahl M, Rasmussen T, Jensen M, Nielsen H Eur J Clin Microbiol Infect Dis. 2024; 43(5):947-957.

PMID: 38512514 PMC: 11108954. DOI: 10.1007/s10096-024-04808-9.

References

Chiu C, Tang P, Chu C, Hu S, Bao Q, Yu J . The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen. Nucleic Acids Res. 2005; 33(5):1690-8. PMC: 1069006. DOI: 10.1093/nar/gki297. View

Winter S, Winter M, Godinez I, Yang H, Russmann H, Andrews-Polymenis H . A rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of Salmonella. PLoS Pathog. 2010; 6(8):e1001060. PMC: 2924370. DOI: 10.1371/journal.ppat.1001060. View

Ochman H, Soncini F, Solomon F, Groisman E . Identification of a pathogenicity island required for Salmonella survival in host cells. Proc Natl Acad Sci U S A. 1996; 93(15):7800-4. PMC: 38828. DOI: 10.1073/pnas.93.15.7800. View

SAPHRA I, Winter J . Clinical manifestations of salmonellosis in man; an evaluation of 7779 human infections identified at the New York Salmonella Center. N Engl J Med. 1957; 256(24):1128-34. DOI: 10.1056/NEJM195706132562402. View

Frey J . The role of RTX toxins in host specificity of animal pathogenic Pasteurellaceae. Vet Microbiol. 2011; 153(1-2):51-8. DOI: 10.1016/j.vetmic.2011.05.018. View

Roof D, Roth J . Ethanolamine utilization in Salmonella typhimurium. J Bacteriol. 1988; 170(9):3855-63. PMC: 211381. DOI: 10.1128/jb.170.9.3855-3863.1988. View

Roumagnac P, Weill F, Dolecek C, Baker S, Brisse S, Chinh N . Evolutionary history of Salmonella typhi. Science. 2006; 314(5803):1301-4. PMC: 2652035. DOI: 10.1126/science.1134933. View

Zarantonelli M, Szatanik M, Giorgini D, Hong E, Huerre M, Guillou F . Transgenic mice expressing human transferrin as a model for meningococcal infection. Infect Immun. 2007; 75(12):5609-14. PMC: 2168318. DOI: 10.1128/IAI.00781-07. View

Santos R, Raffatellu M, Bevins C, Adams L, Tukel C, Tsolis R . Life in the inflamed intestine, Salmonella style. Trends Microbiol. 2009; 17(11):498-506. PMC: 3235402. DOI: 10.1016/j.tim.2009.08.008. View

10.

Dorsey C, Laarakker M, Humphries A, Weening E, Baumler A . Salmonella enterica serotype Typhimurium MisL is an intestinal colonization factor that binds fibronectin. Mol Microbiol. 2005; 57(1):196-211. DOI: 10.1111/j.1365-2958.2005.04666.x. View

11.

McClelland M, Sanderson K, Spieth J, Clifton S, Latreille P, Courtney L . Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001; 413(6858):852-6. DOI: 10.1038/35101614. View

12.

Tsolis R, Adams L, Ficht T, Baumler A . Contribution of Salmonella typhimurium virulence factors to diarrheal disease in calves. Infect Immun. 1999; 67(9):4879-85. PMC: 96822. DOI: 10.1128/IAI.67.9.4879-4885.1999. View

13.

Hodak H, Galan J . A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion. EMBO Rep. 2012; 14(1):95-102. PMC: 3537140. DOI: 10.1038/embor.2012.186. View

14.

Porter S, Curtiss 3rd R . Effect of inv mutations on Salmonella virulence and colonization in 1-day-old White Leghorn chicks. Avian Dis. 1997; 41(1):45-57. View

15.

Bohnhoff M, Miller C . Enhanced susceptibility to Salmonella infection in streptomycin-treated mice. J Infect Dis. 1962; 111:117-27. DOI: 10.1093/infdis/111.2.117. View

16.

Taylor L, Latham S, Woolhouse M . Risk factors for human disease emergence. Philos Trans R Soc Lond B Biol Sci. 2001; 356(1411):983-9. PMC: 1088493. DOI: 10.1098/rstb.2001.0888. View

17.

Winter S, Winter M, Thiennimitr P, Gerriets V, Nuccio S, Russmann H . The TviA auxiliary protein renders the Salmonella enterica serotype Typhi RcsB regulon responsive to changes in osmolarity. Mol Microbiol. 2009; 74(1):175-193. PMC: 2763492. DOI: 10.1111/j.1365-2958.2009.06859.x. View

18.

Lecuit M, Vandormael-Pournin S, Lefort J, Huerre M, Gounon P, Dupuy C . A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier. Science. 2001; 292(5522):1722-5. DOI: 10.1126/science.1059852. View

19.

Wilson R, Raffatellu M, Chessa D, Winter S, Tukel C, Baumler A . The Vi-capsule prevents Toll-like receptor 4 recognition of Salmonella. Cell Microbiol. 2007; 10(4):876-90. DOI: 10.1111/j.1462-5822.2007.01090.x. View

20.

Glynn J, Palmer S . Incubation period, severity of disease, and infecting dose: evidence from a Salmonella outbreak. Am J Epidemiol. 1992; 136(11):1369-77. DOI: 10.1093/oxfordjournals.aje.a116449. View