Circulating FABP4 and FABP5 Levels Are Differently Linked to OSA Severity and Treatment

Overview

Journal Sleep

Publisher Oxford University Press

Specialty Psychiatry

Date 2013 Dec 3

PMID 24293757

Citations 5

Authors

Raquel Catala

Anna Cabre

Salvador Hernandez-Flix

Raimon Ferre

Sandra Sangenis

Nuria Plana

Anna Texido

Lluis Masana

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate circulating adipocyte and epidermal fatty acid-binding protein (FABP4 and FABP5) concentrations in patients with obstructive sleep apnea (OSA), as well as the effects of continuous positive airway pressure (CPAP) treatment.

Methods: Our cross-sectional study included 125 patients. After polysomnography, 58 participants met the criteria for CPAP treatment and were included in a closed cohort study of 8 weeks of CPAP treatment. General anthropometric and biochemical data and circulating FABP4 and FABP5 levels were determined in all patients at baseline and after CPAP treatment in those receiving this therapy.

Results: Circulating FABP4 but not FABP5 levels were higher in patients with OSA (P = 0.003). FABP4 but not FABP5 values were associated with parameters of OSA severity independently of age, gender, adiposity and insulin resistance (P < 0.05). FABP4 but not FABP5 concentrations were determinants of OSA presence (OR: 1.11, P = 0.010) and severity (OR: 1.06, P = 0.020). After CPAP treatment, FABP4 levels decreased in the more severe patients (P = 0.019), while FABP5 levels increased in all patients (P < 0.001).

Conclusions: FABP4 is directly associated with obstructive sleep apnea severity and did not change with continuous positive airway pressure treatment, while FABP5 was not associated with obstructive sleep apnea severity and increased with continuous positive airway pressure treatment. FABP4 and FABP5 have different associations with obstructive sleep apnea. FABP4 but not FABP5 could be considered a marker of metabolic alterations in obstructive sleep apnea patients.

Citing Articles

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.

Meszaros M, Bikov A Biomedicines. 2022; 10(11).

PMID: 36359273 PMC: 9687681. DOI: 10.3390/biomedicines10112754.

Adipocyte Fatty Acid-Binding Protein, Cardiovascular Diseases and Mortality.

Lee C, Lui D, Lam K Front Immunol. 2021; 12:589206.

PMID: 33815359 PMC: 8017191. DOI: 10.3389/fimmu.2021.589206.

Independent and Distinct Associations of FABP4 and FABP5 With Metabolic Parameters in Type 2 Diabetes Mellitus.

Furuhashi M, Sakuma I, Morimoto T, Higashiura Y, Sakai A, Matsumoto M Front Endocrinol (Lausanne). 2020; 11:575557.

PMID: 33071982 PMC: 7538548. DOI: 10.3389/fendo.2020.575557.

Effect of semi-rapid maxillary expansion in children with obstructive sleep apnea syndrome: 5-month follow-up study.

Hoxha S, Kaya-Sezginer E, Bakar-Ates F, Kokturk O, Toygar-Memikoglu U Sleep Breath. 2018; 22(4):1053-1061.

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Gender difference in plasma fatty-acid-binding protein 4 levels in patients with chronic obstructive pulmonary disease.

Zhang X, Li D, Wang H, Pang C, Wu Y, Wen F Biosci Rep. 2016; 36(1):e00302.

PMID: 26823558 PMC: 4770303. DOI: 10.1042/BSR20150281.

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