BDNF Genetic Variability Modulates Psychopathological Symptoms in Patients with Eating Disorders

Overview

Journal Eur Child Adolesc Psychiatry

Specialties Pediatrics
Psychiatry

Date 2013 Dec 3

PMID 24292283

Citations 14

Authors

Carmen Gamero-Villarroel

Inmaculada Gordillo

Juan Antonio Carrillo

Angustias Garcia-Herraiz

Isalud Flores

Mercedes Jimenez

Melchora Monge

Raquel Rodriguez-Lopez

Guillermo Gervasini

Affiliations

Soon will be listed here.

Abstract

The brain-derived neurotrophic factor (BDNF) gene may influence eating behavior, body weight and cognitive impairments. We aimed to investigate whether BDNF genetic variability may affect anthropometric and psychological parameters in patients with anorexia or bulimia nervosa (AN, BN) and/or modulate the risk for the disorder. A total of 169 unrelated female patients and 312 healthy controls were genotyped for two common BDNF single-nucleotide polymorphisms (SNPs), Val66Met and C-270T, and several selected tag-SNPs. Associated personality characteristics and psychopathological symptoms were assessed by the EDI-2 and SCL-90R inventories, respectively. No single SNP or haplotype played a relevant role in the risk for AN or BN. The rs16917237 TT genotype was significantly associated with increased weight (74.63 ± 16.58 vs. 57.93 ± 13.02) and body mass index (28.94 ± 6.22 vs. 22.23 ± 4.77) in the BN group after correcting for multiple testing. Haplotype analyses using a sliding window approach with three adjacent SNPs produced four loci of interest. Locus 3 (rs10835210/rs16917237/C-270T) showed a broad impact on the measured psychopathological symptoms. Haplotypes CGC and CGT in this locus correlated with scores in all three scales of the SCL-90R inventory, both in AN and BN patients. In contrast, the results of the EDI-2 inventory were largely unaffected. These preliminary results suggest that variability in the BDNF gene locus may contribute to anthropometric characteristics and also psychopathological symptoms that are common but not exclusive of ED patients.

Citing Articles

Association of Gene Variants with Changes in Body Weight and Psychometric Indicators in Patients with Eating Disorders.

Gonzalez-Rodriguez L, Gonzalez L, Garcia-Herraiz A, Mota-Zamorano S, Flores I, Gervasini G J Clin Med. 2024; 13(17).

PMID: 39274402 PMC: 11396092. DOI: 10.3390/jcm13175189.

The Role of Central and Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker of Anorexia Nervosa Reconceptualized as a Metabo-Psychiatric Disorder.

Cao J, Gorwood P, Ramoz N, Viltart O Nutrients. 2024; 16(16).

PMID: 39203753 PMC: 11357464. DOI: 10.3390/nu16162617.

Relationship of Genetic Polymorphisms and Microbial Composition with Binge Eating Disorder: A Systematic Review.

Monserrat Hernandez M, Jimenez-Rodriguez D Healthcare (Basel). 2024; 12(14).

PMID: 39057584 PMC: 11276772. DOI: 10.3390/healthcare12141441.

Inclusion of the severe and enduring anorexia nervosa phenotype in genetics research: a scoping review.

Ramsay S, Allison K, Temples H, Boccuto L, Sarasua S J Eat Disord. 2024; 12(1):53.

PMID: 38685102 PMC: 11059621. DOI: 10.1186/s40337-024-01009-9.

Genotype-expression interactions for BDNF across human brain regions.

Devlin P, Cao X, Grimes Stanfill A BMC Genomics. 2021; 22(1):207.

PMID: 33757426 PMC: 7989003. DOI: 10.1186/s12864-021-07525-1.

References

Pinheiro A, Bulik C, Thornton L, Sullivan P, Root T, Bloss C . Association study of 182 candidate genes in anorexia nervosa. Am J Med Genet B Neuropsychiatr Genet. 2010; 153B(5):1070-80. PMC: 2963154. DOI: 10.1002/ajmg.b.31082. View

Kaplan A, Levitan R, Yilmaz Z, Davis C, Tharmalingam S, Kennedy J . A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosa. Int J Eat Disord. 2007; 41(1):22-8. DOI: 10.1002/eat.20474. View

Mercader J, Fernandez-Aranda F, Gratacos M, Aguera Z, Forcano L, Ribases M . Correlation of BDNF blood levels with interoceptive awareness and maturity fears in anorexia and bulimia nervosa patients. J Neural Transm (Vienna). 2010; 117(4):505-12. DOI: 10.1007/s00702-010-0377-8. View

Cordeira J, Rios M . Weighing in the role of BDNF in the central control of eating behavior. Mol Neurobiol. 2011; 44(3):441-8. PMC: 3235948. DOI: 10.1007/s12035-011-8212-2. View

Sole X, Guino E, Valls J, Iniesta R, Moreno V . SNPStats: a web tool for the analysis of association studies. Bioinformatics. 2006; 22(15):1928-9. DOI: 10.1093/bioinformatics/btl268. View

Gervasini G, Gordillo I, Garcia-Herraiz A, Flores I, Jimenez M, Monge M . Influence of dopamine polymorphisms on the risk for anorexia nervosa and associated psychopathological features. J Clin Psychopharmacol. 2013; 33(4):551-5. DOI: 10.1097/JCP.0b013e3182970469. View

Rybakowski F, Dmitrzak-Weglarz M, Szczepankiewicz A, Skibinska M, Slopien A, Rajewski A . Brain derived neurotrophic factor gene Val66Met and -270C/T polymorphisms and personality traits predisposing to anorexia nervosa. Neuro Endocrinol Lett. 2007; 28(2):153-8. View

Sen S, Nesse R, Stoltenberg S, Li S, Gleiberman L, Chakravarti A . A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology. 2003; 28(2):397-401. DOI: 10.1038/sj.npp.1300053. View

McDermott B, Forbes D, Harris C, McCormack J, Gibbon P . Non-eating disorders psychopathology in children and adolescents with eating disorders: implications for malnutrition and symptom severity. J Psychosom Res. 2006; 60(3):257-61. DOI: 10.1016/j.jpsychores.2005.08.004. View

10.

Rask-Andersen M, Olszewski P, Levine A, Schioth H . Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake. Brain Res Rev. 2009; 62(2):147-64. DOI: 10.1016/j.brainresrev.2009.10.007. View

11.

Ribases M, Gratacos M, Armengol L, de Cid R, Badia A, Jimenez L . Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry. 2003; 8(8):745-51. DOI: 10.1038/sj.mp.4001281. View

12.

Amianto F, Abbate-Daga G, Morando S, Sobrero C, Fassino S . Personality development characteristics of women with anorexia nervosa, their healthy siblings and healthy controls: What prevents and what relates to psychopathology?. Psychiatry Res. 2010; 187(3):401-8. DOI: 10.1016/j.psychres.2010.10.028. View

13.

Terracciano A, Tanaka T, Sutin A, Deiana B, Balaci L, Sanna S . BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology. 2010; 35(5):1083-9. PMC: 2840212. DOI: 10.1038/npp.2009.213. View

14.

Gervasini G, Gordillo I, Garcia-Herraiz A, Flores I, Jimenez M, Monge M . Polymorphisms in serotonergic genes and psychopathological traits in eating disorders. J Clin Psychopharmacol. 2012; 32(3):426-8. DOI: 10.1097/JCP.0b013e3182539f2b. View

15.

de Krom M, Bakker S, Hendriks J, van Elburg A, Hoogendoorn M, Verduijn W . Polymorphisms in the brain-derived neurotrophic factor gene are not associated with either anorexia nervosa or schizophrenia in Dutch patients. Psychiatr Genet. 2005; 15(2):81. DOI: 10.1097/00041444-200506000-00003. View

16.

Xie B, Wang B, Suo P, Kou C, Wang J, Meng X . Genetic association between BDNF gene polymorphisms and phobic disorders: a case-control study among mainland Han Chinese. J Affect Disord. 2011; 132(1-2):239-42. DOI: 10.1016/j.jad.2010.12.017. View

17.

Dmitrzak-Weglarz M, Skibinska M, Slopien A, Szczepankiewicz A, Rybakowski F, Kramer L . BDNF Met66 allele is associated with anorexia nervosa in the Polish population. Psychiatr Genet. 2007; 17(4):245-6. DOI: 10.1097/YPG.0b013e3280991229. View

18.

Hong C, Liou Y, Tsai S . Effects of BDNF polymorphisms on brain function and behavior in health and disease. Brain Res Bull. 2011; 86(5-6):287-97. DOI: 10.1016/j.brainresbull.2011.08.019. View

19.

Speliotes E, Willer C, Berndt S, Monda K, Thorleifsson G, Jackson A . Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010; 42(11):937-48. PMC: 3014648. DOI: 10.1038/ng.686. View

20.

Fairburn C, Welch S, Doll H, Davies B, OConnor M . Risk factors for bulimia nervosa. A community-based case-control study. Arch Gen Psychiatry. 1997; 54(6):509-17. DOI: 10.1001/archpsyc.1997.01830180015003. View