Acinetobacter Baumannii: Role in Blood Stream Infection in Neonatal Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Overview

Journal Int J Microbiol

Publisher Wiley

Specialty Microbiology

Date 2013 Nov 30

PMID 24288538

Citations 4

Authors

Enty Tjoa

Lucky Hartati Moehario

Andriansjah Rukmana

Rinawati Rohsiswatmo

Affiliations

Soon will be listed here.

Abstract

Acinetobacter baumannii (A. baumannii) is Gram-negative coccobacilli that has emerged as a nosocomial pathogen. Several reports in Indonesia showed the continuous presence of A. baumannii. This study aimed to determine the incidence of A. baumannii bacteremia in neonates in the Neonatal Unit Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia, and assess its role in blood stream infection using antibiogram and genotyping by pulsed-field gel electrophoresis (PFGE). Subjects were neonates with clinical sepsis. Blood specimens from the neonates and samples of suspected environment within the Neonatal Unit were cultivated. Antimicrobial resistance profiles were classified for analysis purpose. A. baumannii isolates were genotyped by PFGE to determine their similarity. A total of 24 A. baumannii were isolated from 80 neonates and the environment during this period of study. Seven isolates from the neonates showed multiple antimicrobial resistance (MDR), and 82% (n = 17) of the environment isolates were also MDR. Antibiotype "d" seemed to be predominant (62.5%). PFGE analysis showed a very close genetic relationship between the patients and environment isolates (Dice coefficient 0.8-1.0). We concluded that a mode of transmission of environmental microbes to patients was present in the Neonatal Unit of RSCM and thus needed to be overcome.

Citing Articles

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Predictive model for bacterial late-onset neonatal sepsis in a tertiary care hospital in Thailand.

Husada D, Chanthavanich P, Chotigeat U, Sunttarattiwong P, Sirivichayakul C, Pengsaa K BMC Infect Dis. 2020; 20(1):151.

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Clonal diversity and detection of carbapenem resistance encoding genes among multidrug-resistant isolates recovered from patients and environment in two intensive care units in a Moroccan hospital.

Uwingabiye J, Lemnouer A, Roca I, Alouane T, Frikh M, Belefquih B Antimicrob Resist Infect Control. 2017; 6:99.

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