Complications of Diabetes Therapy
Overview
Affiliations
Current strategies for the treatment of type 2 diabetes mellitus promote individualized plans to achieve target glucose levels on a patient-by-patient basis while minimizing treatment related risks. Maintaining glycemic control over time is a significant challenge because of the progressive nature of diabetes as a result of declining β-cell function. This article identifies complications of non-insulin treatments for diabetes. The major classes of medications are reviewed with special focus on target population, mechanism of action, effect on weight, cardiovascular outcomes and additional class-specific side effects including effects on bone. Effects on β-cell function are also highlighted.
Guetat A, Selmi S, Abdelwahab A, Abdelfattah M, Elhaj A, Mogharbel R Front Pharmacol. 2025; 16:1537071.
PMID: 39995414 PMC: 11847675. DOI: 10.3389/fphar.2025.1537071.
Exploring the Biological Effects of Anti-Diabetic Vanadium Compounds in the Liver, Heart and Brain.
Dayanand Y, Pather R, Xulu N, Booysen I, Sibiya N, Khathi A Diabetes Metab Syndr Obes. 2024; 17:3267-3278.
PMID: 39247428 PMC: 11380877. DOI: 10.2147/DMSO.S417700.
Hill J, Messina J, Jeremic A, Zderic V J Ultrasound Med. 2024; 43(6):1131-1141.
PMID: 38414281 PMC: 11093698. DOI: 10.1002/jum.16441.
New-Generation Glucokinase Activators: Potential Game-Changers in Type 2 Diabetes Treatment.
Haddad D, Dsouza V, Al-Mulla F, Madhoun A Int J Mol Sci. 2024; 25(1).
PMID: 38203742 PMC: 10779250. DOI: 10.3390/ijms25010571.
Titisari N, Fauzi A, Abdul Razak I, Samsulrizal N, Ahmad H Open Vet J. 2023; 13(8):983-990.
PMID: 37701670 PMC: 10495088. DOI: 10.5455/OVJ.2023.v13.i8.4.